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  • Electronic Resource  (3)
  • Antiepileptic drugs  (1)
  • Arctic Amerasian shelf Sediment carbon and nitrogen isotopes  (1)
  • Chemical Engineering  (1)
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  • Electronic Resource  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Anticonvulsant drug actions on neurons in cell culture (1988)
    Springer
    Journal of neural transmission 72 (1988), S. 173-183 
    Details
    ISSN: 1435-1463
    Keywords: Antiepileptic drugs ; action potentials ; sodium channels ; GABA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two actions of clinically used antiepileptic drugs have been studied using mouse neurons in primary dissociated cell culture. The antiepileptic drugs phenytoin, carbamazepine and valproic acid were demonstrated to limit sustained high frequency repetitive firing of action potentials at free serum concentratons that are achieved in patients being treated for epilepsy. Furthermore, an active metabolite of carbamazepine also limited sustained high frequency repetitive firing while inactive metabolites of phenytoin and carbamazepine did not limit sustained high frequency repetitive firing. Phenobarbital and clinically used benzodiazepines limited sustained high frequency repetitive firing of action potentials, but only at concentrations achieved during the treatment of generalized tonic-clonic status epilepticus. Ethosuximide did not limit sustained high frequency repetitive firing even at concentrations four times those achieved in the serum of patients treated for generalized absence seizures. Phenobarbital and clinically used benzodiazepines enhanced postsynaptic GABA responses at concentrations achieved free in the serum during treatment of generalized tonic-clonic or generalized absence seizures. However, phenytoin, carbamazepine, valproic acid and ethosuximide did not modify postsynaptic GABA responses at therapeutic free serum concentrations. These results suggest that the ability of antiepileptic drugs to block generalized tonicclonic seizures and generalized tonic-clonic status epilepticus may be related to their ability to block high frequency repetitive firing of neurons. The mechanism underlying blockade of myoclonic seizures may be related to the ability of antiepileptic drugs to enhance GABAergic synaptic transmission. The mechanism underlying management of generalized absence seizures remains unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01243417
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Data reconciliation and parameter estimation in plant performance analysis (1988)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 34 (1988), S. 1-8 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Results of a computer study are reported applying data reconciliation and interpretation techniques to a single-stage flash operation. Measured errors in the process variables are significantly reduced. The techniques are successfully extended to estimate flash efficiency. The flash efficiency is estimated using two methods: (1) a statistically rigorous simultaneous data reconciliation and efficiency estimation procedure, and (2), a faster, nonrigorous sequential procedure. It is found that the simultaneous procedure provides better measured variable and flash efficiency estimates.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690340102
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Organic carbon isotope ratios (δ13C) of Arctic Amerasian Continental shelf sediments (2000)
    Springer
    International journal of earth sciences 89 (2000), S. 522-532 
    Details
    ISSN: 1437-3262
    Keywords: Arctic Amerasian shelf Sediment carbon and nitrogen isotopes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract. Organic matter origins are inferred from carbon isotope ratios (δ13C) in recent continental shelf sediments and major rivers from 465 locations from the north Bering-Chukchi-East Siberian-Beaufort Sea, Arctic Amerasia. Generally, there is a cross-shelf increase in δ13C, which is due to progressive increased contribution seaward of marine-derived organic carbon to surface sediments. This conclusion is supported by the correlations between sediment δ13C, OC/N, and δ15N. The sources of total organic carbon (TOC) to the Amerasian margin sediments are primarily from marine water-column phytoplankton and terrigenous C3 plants constituted of tundra taiga and angiosperms. In contrast to more temperate regions, the source of TOC from terrigenous C4 and CAM plants to the study area is probably insignificant because these plants do not exist in the northern high latitudes. The input of carbon to the northern Alaskan shelf sediments from nearshore kelp community (Laminaria solidungula) is generally insignificant as indicated by the absence of high sediment δ13C values (–16.5 to –13.6‰) which are typical of the macrophytes. Our study suggests that the isotopic composition of sediment TOC has potential application in reconstructing temporal changes in delivery and accumulation of organic matter resulting from glacial–interglacial changes in sea level and environments. Furthermore, recycling and advection of the extensive deposits of terrestrially derived organic matter from land, or the wide Amerasian margin, could be a mechanism for elevating total CO2 and pCO2 in the Arctic Basin halocline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005310000121
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    Paper (German National Licenses)
    Fulltext
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