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  • Electronic Resource  (2)
  • B-cells  (1)
  • Biocompatibility  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of long-term restricted insulin production in obese-hyperglycemic (genotype ob/ob) mice (1976)
    Springer
    Diabetologia 12 (1976), S. 181-187 
    Details
    ISSN: 1432-0428
    Keywords: Mutation ob/ob ; obese mouse ; streptozotocin ; insulin resistance ; hyperphagia ; spontaneous diabetes ; diabetes in mice ; obesity in mice ; hereditary obesity ; obese-hyperglycaemic mice ; B-cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Primary hypersecretion of insulin has been suggested as one possibility for the genetic fault of ob/ob mice. To test this hypothesis, streptozotocin (SZO) was used to reduce permanently insulin secretion in young lean and obese mice. After establishment of hyperglycaemia and weight reduction in treated obese mice (obese-SZO), daily insulin replacement was begun in some (obese-SZO-Ins). Obese-SZO mice maintained insulin levels and body weights similar to lean controls, though they were shorter and fatter, while food intake and blood sugar levels exceeded lean values. Obese-SZO-Ins mice with reduced islet hyperplasia, but great insulin resistance, gained more weight than obese-SZO mice; had high serum insulin and controlled blood glucose; and exhibited hyperphagia. These results suggest that primary hypersecretion of insulin cannot be the genetic defect, as ob/ob mice are hyperphagic, hyperglycaemic, insulin resistant, and “obese” even when insulin levels are restricted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428986
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Biomaterialien – humane Toleranz und Integration (1999)
    Springer
    Der Chirurg 70 (1999), S. 847-857 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Biomaterials ; Biocompatibility ; Process engineering ; Reciprocal technology transfer. ; Schlüsselwörter: Biomaterialien ; Biokompatibilität ; Prozesstechnologien ; wechselseitiger Technologietransfer.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Biokompatible Werkstoffe und zugehörige Prozesstechnologien, mit denen eine optimale Strukur- und Oberflächenkompatibilität von Implantaten erreicht werden soll, werden vorgestellt. „Vital-avital composites“ für das „tissue engineering“, Zellkulturmodelle, poröse Keramiken und abbaubare Polymere werden beispielhaft dargestellt. Ein Hauptaspekt liegt auf der Konvertierung von Resultaten der Grundlagenforschung in klinische Anwendungen und auf dem Austausch von Technologien aus dem nichtmedizinischen in den medizinischen Bereich und umgekehrt.
    Notes: Summary. Biomaterials and related process engineering in order to obtain optimal surface and structural biocompatibility of implants and devices are presented. Vital-avital composites for tissue engineering, cell culture models, porous ceramics and degradable polymers are introduced as examples. Emphasis is laid on the conversion of basic research results into clinical applications and on the exchange of technologies from the non-medical into the medical field and vice versa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050734
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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