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  • Electronic Resource  (5)
  • Polymer and Materials Science  (2)
  • Cancer Chemotherapy  (1)
  • Cell & Developmental Biology  (1)
  • Chronic myelogenous leukemia  (1)
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  • Electronic Resource  (5)
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  • 1
    Electronic Resource
    Electronic Resource
    Endoscopic appearance of the colon and small intestine of a patient with hemorrhagic enteric graft-vs.-host disease (1990)
    Springer
    Diseases of the colon & rectum 33 (1990), S. 695-697 
    Details
    ISSN: 1530-0358
    Keywords: Graft-vs.-host disease ; Colitis ; Colonoscopy ; Chronic myelogenous leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Endoscopic appearance of the gastrointestinal tract of a patient with severe hemorrhagic enteric graft-vs.-host disease (GVHD) is presented. A 29-year-old man with chronic myelogenous leukemia suffered from severe enteric GVHD after allogeneic bone marrow transplantation. Endoscopy showed hemorrhagic ulceration of the upper jejunum, terminal ileum, and colon at the onset of melena. Sections of biopsies were compatible with acute GVHD. Repeat endoscopy showed gradual healing of the lesions after steroid pulse and antilymphocyte globulin therapy, but the patient died of cytomegalovirus pneumonitis 14 months later. Autopsy revealed submucosal fibrosis of the small intestine and colon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02150747
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  • 2
    Electronic Resource
    Electronic Resource
    5-Hydroxytryptamine is emetogenic in the house musk shrew, Suncus murinus (1991)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 344 (1991), S. 564-567 
    Details
    ISSN: 1432-1912
    Keywords: Vomiting ; 5-HT ; 2-Me-5-HT ; 5-HT3 Receptor antagonism ; Cancer Chemotherapy ; House musk shrew (Suncus murinus)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The emetic effects of 5-hydroxytryptamine (5-HT) and 5-HT3 receptor agonists were investigated in the house musk shrew, Suncus murinus. 5-Hydroxytryptamine (5-HT; i.p., i.v., s.c.) and 2-methyl-5-HT (2-Me-5HT; i.p.) but not 5-hydroxyindoleacetic acid (i.p.) or 5-ethoxytryptamine (i.p.) induced emesis with very short latency. Tropisetron (ICS 205-930, a 5-HT3 receptor antagonist, s.c.) blocked the emesis induced by 5-HT (10 mg/kg, i.p.) and 2-Me-5-HT (5 mg/kg, i.p.) with respective ID50 values of 7.8 and 70.9 μg/kg. Pindolol (5-HT1 receptor antagonist) and ketanserin (5-HT2 receptor antagonist) were about 100 times less potent than tropisetron. The emesis induced by 5-HT was prevented by surgical vagotomy but not by pretreatment with a combination of atropine (0.1 mg/kg, s.c.) and hexamethonium (10 mg/kg, s.c.). These results clearly indicate that 5-HT is emetogenic probably through a stimulation of peripheral 5-HT3 receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00170653
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  • 3
    Electronic Resource
    Electronic Resource
    Characteristics of rectifying devices with thin films of polyphthalocyanine (1989)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 190 (1989), S. 2693-2701 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Chemically and thermally stable thin films of polyphthalocyanine were prepared by a simple evaporation-polymerization method. The rectifying characteristics of metal/semiconductor/metal (MSM) type sandwich devices with the film were studied. A Schottky type device metal (Cu, Al, Ti)/polyphthalocyanine/Cu shows reproducible rectifying characteristics when Ti is selected as a counter electrode. The reproducibility is improved by pre-oxidation treatment of the surface of Cu substrate. Best electric parameters for the device are as follows: rectifying ratio = 14; threshold potential difference = 0,61 V; saturation current = 2,5 · 10-6 A · cm-2; barrier height = 0,75 eV; diode ideality parameter = 4,23. Doping of five kinds of quinones [p-benzoquinone (p-BQ), tetrabromo-p-benzoquinone (p-TBBQ) tetrachloro-p-benzoquinone (p-TCBQ) tetrachloro-o-benzoquinone (o-TCBQ) 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ)] and 2,5-cyclohexadien-1,4-diylidenedimalodinitrile (TNCR) in thin films of polyphthalocyanine affected electrocharacteristics in some cases. The diode ideality parameter decreases to 2,17 at 0,90 · 10-6 mol · cm-1 of p-TBBQ, and the rectifying ratio increases to about fourteen times by doping p-TBBQ and p-TCBQ. The doped device shows a rectifying response up to 1 kHz.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1989.021901103
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  • 4
    Electronic Resource
    Electronic Resource
    Graft copolymers of poly(ethylene glycol) (PEG) and chitosan (1997)
    Weinheim : Wiley-Blackwell
    Macromolecular Rapid Communications 18 (1997), S. 547-550 
    Details
    ISSN: 1022-1336
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Graft copolymers of poly(ethylene glycol) (PEG) on a chitosan backbone (PEG-g-chitosan) have been synthesized and their aqueous solution properties were investigated. At pH 6.5 the graft copolymers are 100% soluble, while chitosan phase separates from solution at those conditions. These interesting graft copolymers may be especially suitable as carriers for delivery of anionic drugs, such as proteins, glycosaminoglycans, and DNA plasmids or oligonucleotides.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/marc.1997.030180703
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  • 5
    Electronic Resource
    Electronic Resource
    Suramin interrupts androgen-inducible autocrine loop involving heparin binding growth factor in mouse mammary cancer (Shionogi carcinoma 115) cells (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 154 (1993), S. 254-261 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The androgen-dependent clonal cell line SC-3, derived from Shionogi carcinoma 115, secretes a fibroblast growth factor (FGF)-autocrine growth factor in response to androgen, which is able to bind to FGF receptors. In SC-3 cells, FGF receptor expression is upregulated by the SC-3-derived growth factor, providing a means of amplifying an autocrine loop of cell growth. In the present investigations, the effect of the polysulfonated naphthylurea suramin on this autocrine loop and its amplification in SC-3 cells were studied. Suramin inhibited androgen-dependent growth of SC-3 cells in a concentration-dependent fashion: ∼50% inhibition was observed at 25 μM. [3H]Thymidine incorporation into the cells stimulated with partially purified SC-3-derived growth factor was inhibited by suramin in a similar way. Additionally, suramin inhibited acidic (a) or basic (b) FGF-induced cell proliferation, though relatively high concentrations were necessary to achieve the maximal inhibition. Pretreatment of SC-3 cells with suramin decreased cell surface 125I-bFGF binding without altering dissociation constant (Kd) of the binding sites. When the cells were incubated with 250 μM suramin for 24 h, the maximum binding (Bmax) decreased to almost 50% of the control. Treatment with suramin also decreased the levels of FGF receptor-1 mRNA to a similar extent, whereas it appeared not to affect the levels of β-actin mRNA. Moreover, suramin completely blocked androgen- or bFGF-induced accumulation of FGF receptor-1 mRNA. The inhibitory effects of suramin on FGF receptor expression were reversed by simultaneous addition of high concentrations of bFGF. These results indicate that suramin exerts its potent antiproliferative action on SC-3 cells through inhibition of an androgen-inducible autocrine loop involving SC-3-derived growth factor and FGF receptor. © 1993 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041540207
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