ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Individual chemosensitivity of in vitro proliferating mammary and ovarian carcinoma cells in comparison to clinical results of chemotherapy (1985)

Albrecht, M. ; Simon, W. E. ; Hölzel, F.

Springer

Journal of cancer research and clinical oncology 109 (1985), S. 210-216

add to mindlist on the mindlist

Details

ISSN: 1432-1335

Keywords: Gynecological tumors ; In vitro proliferation assay ; Individual chemosensitivity ; Chemotherapy

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Cell lines established from advanced mammary and ovarian carcinomas were assayed for the inhibition of in vitro proliferation by various antineoplastic drugs. The assays were performed with multiple experimental cultures derived from stock cultures of the tumor cell lines in early passages of the cultivation. As determined by comparison of the 50% inhibition of in vitro growth, differential sensitivity of the individual cell lines was observed. Based on the 2-h plasma level of the drugs as discriminatory threshold between resistance and sensitivity, the in vitro effectiveness of each, drug on the individual cell lines was compared with the clinical results of chemotherapy applied to the corresponding patients. In total, positive in vitro/in vivo correlations were observed in 39 of 42 cases. The 17 cell lines evaluated retrospectively were resistant to those drugs which had been tried unsuccessfully during chemotherapy. Among the 25 cases tried prospectively 11 cases showed sensitivity in vitro and in vivo, and furthermore 11 prospective cases were resistant in vitro and in vivo.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00390360

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Micropreparative system for enrichment of capillary GC effluents (1988)

Nitz, S. ; Drawert, F. ; Albrecht, M. ; [et al.]

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 11 (1988), S. 322-327

add to mindlist on the mindlist

Details

ISSN: 0935-6304

Keywords: Preparative capillary GC ; Multidimensional GC ; Capillary techniques ; Enrichment ; Trace analysis ; Thermal desorption ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: An automated system for preparative gas chromatography with capillary columns is described. The effluet from the capillary column is switched to the FID detector or to the traps by means of a Live-T switching device. The pneumatics is controlled by a microprocessor so that repetitive sampling can be performed over a period of days in order to enrich sufficient amount of material for NMR or other spectroscopic methods. The effluent containing the compounds is collected in glass tubes filled with column packing material (e.g. Chromosorb coated with 3% OV - 101, crosslinked). The trap temperatue can be adjusted from + 20°C to - 80°C, depending on the trapping material and volatility of trapped substances. The analysis of enriched substances or chromatographic fractions can be performed by thermal desorption of the same traps or by solven elution. The recovery of enriched substances is higher than 90%. High capacity and resolution for enrichment of trace components are obtained with the aid of a double column-double oven system. Examples of such applications are given.

Additional Material: 5 Ill.