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  • Electronic Resource  (3)
  • signal transduction  (2)
  • Carbonic anhydrase II  (1)
  • GTP binding protein  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Localization of H+-ATPase and carbonic anhydrase II in ameloblasts at maturation (1994)
    Springer
    Calcified tissue international 55 (1994), S. 38-45 
    Details
    ISSN: 1432-0827
    Keywords: Vacuolar-type H+-ATPase ; Carbonic anhydrase II ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract The localization of vacuolar-type H+-ATPase and carbonic anhydrase II (CA II) in rat incisor enamel organs at maturation was examined by light and electron microscopy. The immunoreactivity for both vacuolar-type H+-ATPase and CA II was intense on the ruffled border of ruffle-ended ameloblasts (RA), but moderate at the distal end of smooth-ended ameloblasts (SA). Immuno-gold particles indicated that CA II was not confined to the ruffled border of RA alone, but also distributed in the cytoplasm of RA and SA. These findings suggest that RA may secrete protons produced by CA II via the ruffled border into enamel by active transport of vacuolar-type H+-ATPase. Secreted protons may activate hydrolytic enzymes to degrade the organic components of enamel matrix. Vacuolar-type H+-ATPase on vesicles of SA suggests that a specific configuration of ruffled borders in RA may be formed by the fusion of vesicle membranes in the distal end of cytoplasm of SA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310167
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Imbalance of the Gs and Gi/o function in post-mortem human brain of depressed patients (1993)
    Springer
    Journal of neural transmission 94 (1993), S. 63-69 
    Details
    ISSN: 1435-1463
    Keywords: Depression ; GTP binding protein ; human brain ; photoaffmity labeling ; signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The amounts of various G protein subunits in postmortem brain samples from the parietal and temporal cortices were the same in controls and depressive patients as demonstrated by immunoblotting. However, photoaffinity GTP labeling (AAGTP) of Gi/oα, but not Gsα, was significantly increased in depressives in both cortex regions. Furthermore, the ratio of Gs/Gi/o AAGTP incorporation revealed a significant reduction in depressives in these regions. The present findings suggest that an imbalance of second messengers via G protein function may be involved in the pathophysiology of depression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244984
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Ca2+/CaM-sensitive adenylyl cyclase activity is decreased in the Alzheimer's brain: Possible relation to type I adenylyl cyclase (1997)
    Springer
    Journal of neural transmission 104 (1997), S. 721-732 
    Details
    ISSN: 1435-1463
    Keywords: Dementia of the Alzheimer type (DAT) ; postmortem human brain ; adenylyl cyclase ; Western blot ; calcium ; calmodulin ; cAMP ; signal transduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunoreactivities of four subtypes of adenylyl cyclase (AC) (types I, II, IV and V/VI), and basal, forskolin- and Mn2+-stimulated AC activities with or without calcium and calmodulin (Ca2+/CaM) were estimated in parietal cortex membranes from cases with dementia of the Alzheimer type (DAT) and age-matched controls. Immunoreactivities of AC-I and AC-II were significantly decreased, but those of AC-IV and AC-V/VI did not change in DAT brains. There was a significant correlation of AC-I immunoreactivity with Ca2+/CaM-sensitive AC activity, but not with the Ca2+/CaM-insensitive activity. Ca2+/CaM-sensitive AC activity was significantly lower in DAT than in the control, indicating that impairment of Ca2+/CaM-sensitive AC-I is clearly involved in the pathophysiology of DAT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01291889
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    Paper (German National Licenses)
    Fulltext
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