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  • Electronic Resource  (2)
  • Cellular infiltration  (1)
  • Dorsal root ganglia  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Chronic progressive sensory ataxic neuropathy: clinicopathological features of idiopathic and Sjögren's syndrome-associated cases (1993)
    Springer
    Journal of neurology 240 (1993), S. 1-7 
    Details
    ISSN: 1432-1459
    Keywords: Chronic ataxic neuropathy ; Sjögren's syndrome ; Cellular infiltration ; Ganglioneuritis ; Idiopathic chronic ataxic neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eleven patients with chronic progressive sensory ataxic neuropathy were examined clinicopathologically. Three cases were associated with primary Sjögren's syndrome (SS-SAN) and the others were considered to be idiopathic (ISAN). The major clinical symptom in both was loss of proprioceptive and kinesthetic sensation with some impairment of superficial sensation, with multifocal and asymmetrical distribution and progression. The truncal and trigeminal nerves were frequently involved. The motor system was substantially preserved. These somatic sensory and motor symptoms did not differ between ISAN and SS-SAN, but autonomic nervous system signs were more frequent in SS-SAN. Polyclonal elevations of serum IgG and/or IgA were seen in 8 patients. One autopsied case with ISAN combined with previous reports suggested that systemic T-and B-cell infiltration into the nervous tissues, as well as a wide variety of the visceral organs, may be a common finding in ISAN and SS-SAN, and could participate in the cause of this neuropathy and polyclonal hypergammaglobulinaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00838437
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Expression of low-affinity neurotrophin receptor p75NTR in the peripheral nervous system of human neuropathies (1998)
    Springer
    Acta neuropathologica 95 (1998), S. 597-604 
    Details
    ISSN: 1432-0533
    Keywords: Key words p75NTR ; Nerve regeneration ; Spinal cord ; Dorsal root ganglia ; Sympathetic ganglia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Expression of low-affinity neurotrophin receptor (p75NTR) was immunohistochemically examined in the peripheral nerve trunks, dorsal root ganglia, sympathetic nerve ganglia and spinal cords in various human neurological diseases manifesting peripheral neuropathies. p75NTR was expressed in the nerves with axonal degeneration, and was also prominent in the nerves with newly regenerating axons. In contrast, axonal pathology tended to reduce the expression of p75NTR in the neuronal perikarya of the dorsal root genglion and sympathetic nerve ganglion neurons. In the ventral and lateral horn cells, the p75NTR immunoreactivity was not detected in the normal and diseased nerves except for amyloid polyneuropathy. These p75NTR expressions in the diseased human peripheral nervous tissues would be regulated by an underlying pathology-related process, and could play a role in peripheral nerve repair.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050846
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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