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  • Electronic Resource  (2)
  • Chemical Engineering  (1)
  • Syrian hamster  (1)
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  • Electronic Resource  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cell biology and toxicology 4 (1988), S. 349-356 
    ISSN: 1573-6822
    Keywords: pancreatic islets ; streptozotocin ; Syrian hamster ; tissue culture ; toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Pancreatic islets of the Syrian golden hamster were maintained in culture for extended periods of time. Toxicity of streptozotocin in these cultures was evaluated by measurement of insulin secretion. Exposure of islets to 1 or 2 mM streptozotocin immediately following isolation resulted in a permanent and dose-related inhibition of insulin secretion. This was accompanied by islet disruption as observed by phase-contrast microscopy. Culture of islets for 24 hours before streptozotocin exposure afforded protection from toxicity. For example, exposure of freshly isolated islets to 2 mM streptozotocin resulted in complete destruction of beta cells, whereas islets similarly exposed after a 24 hr culture period continued to secrete insulin for many months. Islets maintained in culture for one week before exposure to 0.1–0.5 mM streptozotocin, however, became more sensitive than freshly isolated islets. Repeated weekly exposure of cultured islets to a “non-toxic” concentration (0.1 mM) resulted in sustained suppression of insulin secretion after 11 weeks.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 22 (1976), S. 1079-1090 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Prospects for enzymatic synthesis processes on an industrial scale depend upon development of a practical process for ATP regeneration. The relative merits of various routes to ATP regeneration involving chemical synthesis, whole cells or organelles, or cell free enzymes are evaluated. The most promising route involves one or more enzyme incorporating the reaction catalyzed by acetate kinase for ADP phosphorylation.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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