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  • 1
    Electronic Resource
    Electronic Resource
    ESHAP is an active regimen for relapsing Hodgkin's disease (1999)
    Springer
    Annals of oncology 10 (1999), S. 593-595 
    Details
    ISSN: 1569-8041
    Keywords: Hodgkin's disease ; relapse ; salvage chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Refractory or relapsing Hodgkin's disease is associated with a poor prognosis. There is no widely accepted salvage chemotherapy regimen for these patients. However, the addition of high-dose chemotherapy followed by autologous hematopoietic transplantation (AHT) has proven of benefit to them. A prospective clinical trial was carried out to evaluate the efficacy and toxicity of ESHAP (etoposide, methylprednisolone, high-dose cytarabine, and cisplatin). Patients and methods: Twenty-two patients with refractory (5) or relapsing Hodgkin's disease (17) were entered and scheduled to receive three courses of ESHAP. Patients suitable for AHT were then given high-dose chemotherapy with CBV (cyclophosphamide, carmustine, and etoposide) plus AHT, whereas responding, non-AHT-suitable patients completed six ESHAP courses. Results: Nine patients achieved complete responses and seven partial responses (overall response rate 73%) with ESHAP. Grade 3–4 myelotoxicity was seen in 13 patients (59%). Nine patients received CBV plus AHT. At a median follow-up time of 50 months (range 6–96), seven patients (32%) are alive and disease-free. Three patients died of toxic effects of ESHAP (1) or CBV (2). Actuarial overall survival and disease-free survival were 35% and 27% at three years. Conclusions: ESHAP is an active regimen for relapsing Hodgkin's disease, with myelosuppression as its dose-limiting toxicity. An increased risk of treatment-related mortality when it is combined with high-dose chemotherapy can not be ruled out.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026454831340
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  • 2
    Electronic Resource
    Electronic Resource
    A statistical study of the correlation between k′ or log k′ and log Pow for a group of benzene and naphthalene derivatives in micellar liquid chromatography using a C-18 column (1995)
    Springer
    Chromatographia 40 (1995), S. 185-192 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Micellar liquid phases ; Octanol-water partition coefficient ; Benzene and naphthalene derivatives
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary It is shown that the logarithm of the capacity factor (log k′) for fifteen benzene and naphthalene derivatives in micellar liquid chromatography with forty nine different mobile phases generally correlates better with the logarithm of the octanol-water partition coefficient (log Pow) than the capacity factor (k′). Optimum conditions are established to obtain the best linear correlations of log k′-log Pow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02272169
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of the catalyst on the kinetics of a RIM formulation (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 38 (1989), S. 237-248 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The influence of three different catalysts [triethylendiamine (TD), stannous octoate (SO), and dibutylindilaurate (DBTDL)] and their blends (TD + SO and TD + DBTDL) on the kinetics of a RIM formulation, based on a high functionality polyether-polyol and a polymeric MDI, has been studied using the adiabatic temperature rise method and Fourier transform infrared spectroscopy. The synergism observed in the DBTDL/TD systems is explained by means of complex formation between the amine-based and metal-based catalysts. Infrared spectroscopy data support this complex formation. The SO/TD systems do not exhibit synergetic behaviour, being the reaction rate controlled by the metal catalyst which complexes the isocyanate group.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1989.070380204
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    Paper (German National Licenses)
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