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  • Electronic Resource  (3)
  • Chemistry  (2)
  • Fc receptors  (1)
  • 1
    ISSN: 1432-0584
    Keywords: Monocytes ; Macrophages ; Fc receptors ; Intravenous Immunoglobulin ; Phagocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The capacity of immunoglobulin for intravenous application (IgG-IV) to interact with Fc receptors of human monocytes and macrophages was tested by quantifying the inhibition of phagocytosis of IgG-sensitized erythrocytes. To this end a spectrometric phagocytosis test has been used. When compared with IgG for i.m. use (IgG-IM), all IgG-IV had reduced activity. This reduction was related, in part, to the reduced amount of IgG dimers and polymers in IgG-IV. On a weight basis dimeric IgG and polymeric IgG exerted 6-fold and 14-fold higher activity, respectively, than monomeric IgG. When this difference was corrected for, chemically modified IgG-IV still had significantly reduced inhibitory activity; DEAE-Sephadex-treated IgG and acid-treated IgG had an activity similar to IgG-IM, and PEG-treated IgG showed a slightly reduced activity. Pepsin-treated IgG was 〉100-fold less active than IgG-IM. The reactivity of IgG-IV with monocyte and macrophage Fc receptors was closely correlated. The most conspicuous differences found were related to the concentration at which IgG was used. Thus, β-propiolactone-treated IgG and plasmin-treated IgG were found to have significantly reduced activity at concentrations 〉20 μg/ml, but almost normal activity when used at lower concentrations.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two radiochemical methods for the quantitative determination of tantalum and niobium, with the aid of 182Ta and 95Nb, are described. If only one of these radio-isotopes is present, it can be determined by counting the gamma radiation emitted in a well-cristal scintillator. The simultaneous determination of both Ta and Nb is possible by the interpretation of the entire spectrum obtained in the presence of both radioisotopes.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: La structure des orthophosphates de calcium étudiés, obtenus par diverses méthodes à l'état microcristallin, a été examinée à l'aide de la diffraction des rayons X et des électrons, du microscope électronique, de la mesure de la surface spécifique, de la thermogravimétrie et de l'analyse thermique différentielle. Les dimensions et les surfaces spécifiques des microcristaux et de leurs agrégats ont été déterminées; quant à la forme et à l'orientation des axes des microcristaux, il s'agit de longues aiguilles prismatiques à base hexagonale pour l'hydroxylapatite calcique et pour le phosphate tricalcique hydraté; le phosphate dit octocalcique est au contraire formé par des plaques, à cǒté d'un important matériel amorphe. Les résultats obtenus à I'aide de méthodes de diffraction et de la micrographie électronique appliquées à des produits chauffés à diverses températures jusqu' à 1000° confirment ceux de la thermogravimétrie et de l'analyse thermique différentielle.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
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