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Digitale Medien

The sequence-specific nuclear matrix binding factor F6 is a chicken GATA-like protein (1993)

Vassetzky, Y. S. ; Moura Gallo, C. V. ; Bogdanova, A. N. ; [weitere]

Springer

Molecular genetics and genomics 238 (1993), S. 309-314

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Details

ISSN: 1617-4623

Schlagwort(e): Nuclear matrix attachment ; GATA ; Chicken globin genes ; DNA-binding protein

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Abstract The sequence-specific DNA-binding protein factor F6, which binds upstream of the cluster of the chicken α-globin genes, has previously been found to interact with a DNA fragment containing a replication origin and a nuclear matrix binding site. This protein has been partially characterized. Based on its molecular weight and binding affinity, F6 belongs to a family of GATA proteins, the chicken equivalent of transcription factor NFE-1. An oligonucleotide including the binding site for F6 competes for binding of the above-mentioned DNA fragment to the nuclear matrix. This indicates an involvement of this protein in the interaction between DNA and the nuclear matrix.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00291988

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Digitale Medien

DNA interactions with the nuclear matrix and spatial organization of replication and transcription (1987)

Razin, S. V.

New York, NY : Wiley-Blackwell

BioEssays 6 (1987), S. 19-23

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Details

ISSN: 0265-9247

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: Analysis of the DNA sequence associated with the nuclear matrix has made it possible to identify several types of DNA matrix association. Permanent attachment sites are detected in both transcriptionally active and inactive nuclei. Furthermore, replication origins have been shown to be permanently attached to the nuclear matrix. In transcriptionally active nuclei, expressed genes are also associated with the nuclear matrix. Finally, a special group of attachment sites is described; these sites are believed to maintain the fixed positions of individual chromosomes in interphase nuclei.

Zusätzliches Material: 2 Ill.