ISSN:
1432-2013
Keywords:
Salivary glands
;
Chloride channels
;
Chloride activity
;
Ion-selective microelectrodes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Double-barrelled, chloride-selective microelectrodes were used to study mandibular gland acinar cells at rest and during cholinergic stimulation. At rest, intracellular chloride activity was five times the expected equilibrium activity. During sustained stimulation with acetylcholine, chloride activity fell to three times the expected equilibrium activity. Thus, the gradient for chloride exit was reduced in the stimulated cell. These results lead to the conclusion that stimulation increases the permeability of the acinar cell to chloride. Experiments in which extracellular chloride was removed provided evidence that the permeability increase was due to opening of chloride channels located principally in the apical membrane of the acinar cell.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00580864
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