ISSN:
1432-0533
Keywords:
Ischemia
;
CA-1 delayed neuron death
;
Postischemic hyperactivity
;
Somatostatin
;
Cholecystokinin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Somatostatin (SS)- and cholecystokinin (CCK)-immunopositive cell somata in the rat hippocampus were quantitated at day 1, 2, 3 and 4 after cerebral ischemia. A significant (P〈0.01) 60%–80% loss of hilar and CA-3c SS neurons took place. No CCK neurons were lost. Damage to SS neurons was significant on the second postischemic day and preceded the delayed loss of CA-1 neurons. We speculate that loss of SS neurons, which presumably innervate the inhibitory GABAergic (γ-aminobutyric acid) interneurons, may induce hyperactivity stimulating the Ca-1 neurons to death.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00693775
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