ISSN:
1432-2072
Keywords:
Oral dyskinesia
;
Chronic neuroleptic
;
Vacuous chewing movements
;
Movement disorder
;
Tardive dyskinesia
;
Nigral glutamic acid decarboxylase
;
Striato-nigral GABA-ergic system
;
Rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Following eight monthly haloperidol decanoate injections rats showed an increased rate of vacuous chewing movements (VCM's), which gradually disappeared within 4 drug-free months. Another single dose of non-decanoate haloperidol reinstated a second increase in VCM rate which was still significant after 2 months. The glutamic acid decarboxylase (GAD) activity in the substantia nigra of these chronically haloperidol-treated rats was lower than untreated controls. Furthermore, there was a significant negative correlation between individual VCM rates and nigral GAD activity. No corresponding changes occurred in other brain regions. The depression of nigral GAD may reflect a reduced tissue density of GABA-ergic axon terminals within the descending striato-nigral pathway.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00427260
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