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  • Electronic Resource  (4)
  • General Chemistry  (3)
  • Controlled release  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Controlled-release levodopa/benserazide (Madopar HBS): clinical observations and levodopa and dopamine plasma concentrations in fluctuating parkinsonian patients (1990)
    Springer
    Journal of neurology 237 (1990), S. 24-28 
    Details
    ISSN: 1432-1459
    Keywords: Parkinson's disease ; Controlled release ; Levodopa ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In five levodopa (l-dopa)-treated patients with Parkinson's disease with severe fluctuations of motor performance, plasma l-dopa as well as dopamine levels were measured during 2 days, first under optimal standard l-dopa with peripheral decarboxylase inhibitor (PDI) and then after a dose adjustment period using slow-release l-dopa/benserazide (Madopar HBS) in an open inpatient trial. Three patients benefited from the slow-release preparation; two patients deteriorated with a tendency to have an unpredictable response, a delay to turn “on” with the first dose in the morning, as well as an increase in dyskinesia corresponding to l-dopa cumulation during the day. These problems were subsequently also seen during the follow-up period of 1 year in those patients who benefited from Madopar HBS as inpatients. This might indicate that patient compliance is more difficult with the new formulation. After 1 year all patients had returned to their previous standard l-dopa/PDI treatment. l-Dopa levels continued to fluctuate, but to a lesser degree with Madopar HBS. The equivalent l-dopa dosage had to be increased by 56% (29–100%) with Madopar HBS while mean dopamine levels increased in four patients (by 47–257%) without the occurrence of peripheral side-effects. This implies that with the new formulation more l-dopa is metabolized to dopamine and explains the necessity to increase the equivalent l-dopa dosage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319663
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  • 2
    Electronic Resource
    Electronic Resource
    Entwicklung von Sauerstoff aus dem Kipp'schen Apparat (1890)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 3 (1890), S. 79-80 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.18900030305
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  • 3
    Electronic Resource
    Electronic Resource
    Zur gasvolumetrischen Analyse (1891)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 4 (1891), S. 332-339 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.18910041105
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  • 4
    Electronic Resource
    Electronic Resource
    Zur gasvolumetrischen Analyse (1891)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 4 (1891), S. 450-451 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.18910041509
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    Paper (German National Licenses)
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