Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 177 (1980), S. 43-52 
    ISSN: 1433-8580
    Keywords: Pulmonary embolism ; Copolymer granules ; Dog ; Pulmonary hypertension ; Arteriitis ; Lungenembolie ; Kopolymergranulate ; Hund ; pulmonale Hypertonie ; Arteriitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit dem Ziel, eine pulmonale Hypertonie zu erzeugen, wurden 10 Hunden Kopolymer-Kügelchen (Durchmesser 35–300 µm) i.v. injiziert. Obwohl über Monate hinweg bis zu 15g Granulate embolisiert wurden, stieg bei keinem Tier der Druck im kleinen Kreislauf dauerhaft an. Die histologische Untersuchung der Lunge ergab, daß die Kügelchen nach kurzer Zeit vorwiegend extravasal liegen. Eine nektrotisierende Entzündung zerstört die Arterienwand und erlaubt den Kügelchen, das Gefäß zu verlassen. Das entzündliche Granulationsgewebe verhindert eine wesentliche Blutung. Die Entzündung klingt nach einigen Monaten ab und hinterläßt ein freies und intaktes Gefäß.
    Notes: Summary Copolymer granules (diameter 35–300 µm) were injected i.v. in 10 dogs to produce pulmonary hypertension. Not in a single dog, however, pulmonary pressure arose permanently, though up to 15g of granules had been embolized over several months. Histological examination of the lung revealed that the granules are situated mainly outside the arteries. Necrotizing arteritis destroys the vessel wall and allows the emboli to leave the lumen. Abundant granulation tissue prevents severe hemorrhage. The inflammatory process decreases after months, leaving the vessel wall patent and free of emboli.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-0584
    Keywords: Key words Amyloidosis ; Melphalan ; Peripheral blood stem cell transplantation ; Dimethyl sulfoxide ; Cardiac arrest
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Amyloidosis (AL) is a rapidly fatal plasma cell dyscrasia causing progressive multiorgan failure. Recently, substantial improvement of survival was reported following high-dose chemotherapy with peripheral blood stem cell (PBSC) rescue. We describe a patient with AL with severe cardiac and renal involvement who received high-dose melphalan followed by fractioned autologous PBSC transplantation (455 ml on day 1 and 350 ml on day 2). Immediately after the second infusion of the PBSCs, life-threatening cardiac arrhythmias occurred and, despite intensive treatment, the patient died less than 24 h later. The infusion of cryopreserved PBSCs may be associated with complications, including cardiac toxicity. Dimethyl sulfoxide (DMSO) is the most frequently used cryopreservation agent. In the present case, we suggest that DMSO could have played an important role in causing the fatal cardiac arrhythmias. The mechanisms of the cardiovascular effects of DMSO and the possible preventive measures are discussed. Given the poor prognosis of AL and the promising results of dose-intensive chemotherapy with autologous PBSC transplantation, careful patient selection and intensive monitoring are mandatory in order to further pursue this therapeutic approach.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...