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Digitale Medien

Effects of b-adrenoceptor-blockade on stress-induced adrenocorticotrophin release in humans (1998)

Oberbeck, R. ; Schürmeyer, T. ; Jacobs, R. ; [weitere]

Springer

European journal of applied physiology 77 (1998), S. 523-526

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Details

ISSN: 1439-6327

Schlagwort(e): Key words Adrenocorticotrophin ; Cortisol ; Catecholamines ; Propranolol ; Stress

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract We investigated the mechanisms of stress-induced alterations in adrenocorticotrophin (ACTH) release. Tandem parachutists received either a placebo or the β-adrenoceptor antagonist propranolol prior to a first time parachute jump. Blood samples were drawn 4 h before, immediately after, and 1 h after the jump. Cortisol and catecholamine concentrations displayed a significant stress-induced increase in both groups. The ACTH plasma concentrations significantly increased in the placebo and the propranolol group, with significantly more pronounced changes in the propranolol-treated subjects compared to the placebo group. These data demonstrated a stress-induced increase of ACTH plasma concentrations in humans that was enhanced by β-blockade.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/s004210050370

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