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Digitale Medien

Structural studies on FK-506, cyclosporin A and their immunophilin complexes (1994)

Clardy, Jon

Springer

Perspectives in drug discovery and design 2 (1994), S. 127-144

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ISSN: 1573-9023

Schlagwort(e): Immunophilin ; FK-506 binding protein ; FKBP ; Cyclophilin ; X-ray structure ; Active site-ligand interactions ; Calcineurin

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Notizen: Summary The immunosuppressants FK-506 and cyclosporin A (CsA), along with their macromolecular receptors FKBP12 and cyclophilin A (CyPA), have become important targets for structure-based drug design. In the last few years X-ray diffraction and NMR spectroscopy have combined to provide high-resolution structures of FK-506, CyA, FKBP12, CyPA, FKBP12-FK-506, CyPA-CyA, and other complexes. This review summarizes these structural studies and some of their implications. Because the immunosuppressant-immunophilin complex forms a composite binding surface that interacts with yet another protein, structure-based drug design in this area is unusually challenging.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF02171740

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Digitale Medien

Gilmaniellin and Dechlorogilmaniellin, Two Novel Dimeric OxaphenalenonesDedicated to Prof. Edgardo Giovannini on the occasion of his 70th birthday (1979)

Chexal, Kuldip K. ; Tamm, Christoph ; Hirotsu, Ken ; [weitere]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 62 (1979), S. 1785-1803

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The structure and configuration of gilmaniellin, a metabolite of Gilmaniella humicola BARRON, has been shown to be 2 by X-ray analysis. By comparison of spectral data structure 1 has been assigned to dechlorogilmaniellin.

Zusätzliches Material: 3 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19790620611

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Digitale Medien

The Absolute Configuration of the Fungal Metabolite Verrucarin B. Biosynthetic Consequences. Verrucarins and roridins, 36th communication (1979)

Breitenstein, Werner ; Tamm, Christoph ; Arnold, Edward V. ; [weitere]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 62 (1979), S. 2699-2705

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The absolute configuration of verrucarin B (2) has been determined by a single crystal X-ray diffraction analysis. This result permits the stereochemistry of the biogenetic transformation of mevalonic acid (12) to verrucarinic acid (7) to be deduced.

Zusätzliches Material: 1 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19790620820

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Digitale Medien

Defense Allomones of the Nudibranch Phyllidia varicosa Lamarck 1801 (1979)

Hagadone, Mark R. ; Burreson, B. Jay ; Scheuer, Paul J. ; [weitere]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 62 (1979), S. 2484-2494

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The defensive secretion of the nudibranch Phyllidia varicosa consists of two isocyanosesquiterpenes: the previously described 9-isocyanopupukeanane (1), and its 2-isomer (4), for which we report the structure and properties. The mixture originates with a sponge, Hymeniacidon sp., where it is produced in varying proportions. CD. measurements and X-ray diffraction data establish the absolute configuration of the two metabolites.

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19790620742

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Digitale Medien

Antifungal Diketopiperazines from Symbiotic Fungus of Fungus-Growing Ant Cyphomyrmex minutus (1999)

Wang, Yong ; Mueller, Ulrich G. ; Clardy, Jon

Springer

Journal of chemical ecology 25 (1999), S. 935-941

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ISSN: 1573-1561

Schlagwort(e): Antifungal ; diketopiperazine ; Cyphomyrmex minutus ; fungus-growing ant ; symbiosis ; Tyridiomyces formicarum

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Chemie und Pharmazie

Notizen: Abstract The attine fungus Tyridiomyces formicarum, the symbiont of the fungus-growing ant Cyphomyrmex minutus, produces several antifungal diketopiperazines. This represents the first identification of antifungal compounds from an attine symbiont and contradicts previous suggestions that attine fungi do not produce metabolites with antifungal activity. T. formicarum probably produces antifungal compounds in defense (1) against other fungi that invade the gardens and escape the weeding activity of the ants, or (2) against ant-pathogenic fungi that could harm the host ants. Fungi cultivated by fungus-growing ants may represent a rich source of additional bioactive metabolites.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1020861221126

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Digitale Medien

Gilmicolin and Mycorrhizinol, Two New Metabolites of Gilmaniella humicolaBARRON (1979)

Chexal, Kuldip K. ; Tamm, Christoph ; Clardy, Jon ; [weitere]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 62 (1979), S. 1129-1142

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The structure of gilmicolin and mycorrhizinol, two new metabolites isolated from culture filtrates of Gilmaniella humicola BARRON, have been shown to be 3 and 15 respectively by spectral and chemical studies. The X-ray analysis of gilmicolin (3) is also reported.

Zusätzliches Material: 1 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19790620423

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