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  • Electronic Resource  (2)
  • D-1 Blockade  (1)
  • Polymer and Materials Science  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Biochemical and behavioural properties of clozapine (1989)
    Springer
    Psychopharmacology 99 (1989), S. S6 
    Details
    ISSN: 1432-2072
    Keywords: Clozapine ; D-1 Blockade ; Behavioural effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The selection and early development of clozapine was based upon its gross behavioural, arousal-inhibiting, sleep-promoting, and caudate spindle-prolonging properties. Compared to classical neuroleptics, clozapine causes only a short-lasting elevation of plasma prolactin levels, elevates both striatal homovanillic acid and dopamine content, is devoid of marked apomorphine-inhibitory or cataleptogenic activity and fails to induce supersensitivity of striatal dopaminergic systems after chronic administration. Clozapine's intrinsic anticholinergic activity, while stronger than that of other neuroleptic agents, does not appear to underlie either its failure to induce tardive dyskinesias or its superior antipsychotic activity. Furthermore, the overlap between clozapine and several classical neuroleptics with regard to alpha-adrenergic-, serotonin- and histamine-blocking activity makes it unlikely that one or more of these properties is the key to its atypical characteristics. More recent findings show that clozapine and classical neuroleptics differ with regard to their indirect effects on nigral GABA-ergic mechanisms implicated in the induction of tardive dyskinesias and, possibly in keeping with this, that clozapine and similar agents exhibit preferential blockade of D-1 dopamine receptors in the whole animal. Such an action of clozapine in man could well explain both its low EPS liability and, in some subjects, its superior antipsychotic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442552
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The surface tension of viscous polymers at high temperatures (1960)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 3 (1960), S. 118-121 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The maximum bubble pressure method for the determination of surface tension has been modified for use with thermally unstable, viscous, opaque polymers at high temperatures. A value of 35.1 dynes/cm. was obtained for nylon 66 at 285°C. The order of this value and those for other polymers has been compared with the values for simpler compounds. Further evidence for the persistence of association between polyamide molecules in the molten state is presented.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1960.070030717
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    Paper (German National Licenses)
    Fulltext
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