ISSN:
1573-6903
Keywords:
Energy metabolism
;
non-synaptic and synaptic mitochondria
;
Parkinson's disease
;
MPTP toxicity
;
dihydroergocriptine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The maximal rates (Vmax) of some mitochondrial enzyme activities related to energy transduction (citrate synthase, succinate dehydrogenase, malate dehydrogenase, NADH-cytochrome c reductase, cytochrome oxidase) and amino acid metabolism (glutamate dehydrogenase, glutamate-pyruvate-and glutamate-oxaloacetate-transaminases) were evaluated in non-synaptic (“free”) and intrasynaptic “light” and “heavy” mitochondria fromhippocampus ofMacaca fascicularis (Cynomolgus monkey). The different mitochondrial populations were isolated from thehippocampus of monkeys treated p.o. with dihydroergocriptine at a dose of 12 mg/kg/day before and during the induction of a Parkinson's-like syndrome by MPTP administration (i.v., 0.3 mg/kg/day for 5 days). The MPTP administration modified the activity of some enzymes related to the metabolism of glutamate and the activity of succinate dehydrogenase on selected types of mitochondria. Pharmacological treatment by dihydroergocriptine promoted return to the steady-state levels of most enzymes, demonstrating a protective effect on these biochemical parameters.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00967293
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