ISSN:
1433-8491
Keywords:
Schizophrenia
;
Association study
;
Dopamine receptors (DRD2, DRD4)
;
Tyrosine hydroxylase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Dopamine receptor dysfunction and altered tyrosine hydroxylase activity have both been implicated in the pathophysiology of schizophrenia. Schizophrenic pationts and control subjects were examined for allele frequencies in the tyrosine hydroxylase and dopamine D2 and D4 receptor genes. No significant differences of allele or genotype frequencies were found between the two groups after adjustment for multiple comparison. Neither were any significant relationships observed between allele frequencies and a number of clinical variables within the schizoprenic subsample. When no adjustment was made for multiple testing a few significant tendencies were obtained which warrant further research in extended patient and control materials. The results are compatible with the view that the tyrosine hydroxylase, dopamine receptor D2 and D4 gene polymorphisms examined are not of major importance in the aetiology or pathophysiology of schizophrenia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02189022
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