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  • 1
    Electronic Resource
    Electronic Resource
    Influence of glomerular filtration rate on renal PAH secretion rate in the rat kidney (1978)
    Springer
    Pflügers Archiv 375 (1978), S. 131-139 
    Details
    ISSN: 1432-2013
    Keywords: PAH clearance ; PAH extraction ; Glomerular filtration rate ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PAH secretion (TPAH) was studied in rats at spontaneously occurring glomerular filtration rate (GFR). At saturated transport, TPAH was found to be correlated to GFR. This relationship was also observed at unsaturated transport where TPAH depends upon the PAH concentration in arterial plasma. However, no significant correlation between TPAH and renal PAH load or renal plasma flow rate was found when the effects of GFR were removed by partial correlation analysis. A dependency of TPAH on GFR explains the correlations found between filtration fraction (FF) and renal PAH extraction (EPAH) or renal tubular PAH extraction fraction (EPAH-FFPAH). Thus, even at low PAH concentration in a. plasma, renal PAH extraction may only be assumed to be constant if the filtration fraction is constant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584235
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence for cholinergic dilatatory receptors in pial arteries of cats (1974)
    Springer
    Pflügers Archiv 347 (1974), S. 199-208 
    Details
    ISSN: 1432-2013
    Keywords: Atropine ; Acetylcholine ; Vascular Smooth Muscle ; Cholinergic Control of Cerebral Blood Flow ; Local Arteriolar Reactions ; Cerebral Arteriolar Resistance ; Carbachol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to evaluate the existence of cholinergic receptors at pial arteries the vasoactive effect of the parasympathomimetic substance carbachol was tested by microapplication into the perivascular space of single pial arteries. Concentration response curves revealed no change in vascular diameter for 10−9 to 10−7 M carbachol. From 10−6 to 10−3 M carbachol dilatations were measured with a maximal reaction at 10−5 M. The carbachol-induced dilatations can be stepwise reduced by ascending pervascular concentrations of atropine thus indicating a competitive antagonism at pial arteries. A cholinergic component influencing pial arterial tone was not found under our experimental conditions since microapplication of atropine (10−9 to 10−4 M) did not induce changes in pial arterial diameter. The dilatation at 10−3 M atropine is believed to be unspecific.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00592597
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Micropuncture evaluation of β-receptors in pial arteries of cats (1974)
    Springer
    Pflügers Archiv 348 (1974), S. 293-303 
    Details
    ISSN: 1432-2013
    Keywords: Propranolol ; Isoproterenol ; Vascular Smooth Muscle ; Local Arteriolar Reactions ; Cerebral Arteriolar Resistance ; Autoxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The existence of β-receptors and their possible contribution to the vascular tone of pial arteries was investigated using the microapplication technique combined with the measurement of vascular diameter. Concentration response curves for (+) and (−)propranolol revealed an identical course with no vascular reaction occurring between 2.5×10−10 and 2.5×10−5 M propranolol. Since both (+) and (−)propranolol were without effect on vascular diameter over a wide concentration range it is concluded that the vascular tone is not influenced by β-receptors under these experimental conditions. The increase in vascular diameter (60%) observed at 2.5×10−4 M (+) and (−)propranolol is supposed to be due to an unspecific effect. Concentration response curves for isoproterenol revealed no vascular reaction between 2.5×10−11 and 2.5×10−8 M, dilations of 4–5% at 2.5×10−7 and 2.5×10−6 M, constrictions of about 5% at 2.5×10−4 and of 3% at 1.25×10−3 M isoproterenol. These weak vascular reactions cannot be explained by reduced biological activity of isoproterenol due to autoxidation during storage. It is concluded that β-receptors are of little or no physiological significance for regulation of the vascular tone of pial arteries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00589219
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    Paper (German National Licenses)
    Fulltext
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