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  • 1
    Electronic Resource
    Electronic Resource
    Neuroendocrine effects of apomorphine in chronic schizophrenic patients under long-term neuroleptic therapy and after drug withdrawal: Relations to psychopathology and tardive dyskinesia (1984)
    Springer
    Psychopharmacology 84 (1984), S. 436-440 
    Details
    ISSN: 1432-2072
    Keywords: Chronic schizophrenics ; Long-term neuroleptic therapy ; Neuroleptic withdrawal ; Growth Hormone ; Prolactin ; Psychopathology ; Tardive Dyskinesia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The sensitivity of the dopaminergic hypothalamic pituitary system, as indicated by growth hormone (GH) release after apomorphine (0.5 mg SC), was studied in 11 chronic schizophrenic in-patients under long-term neuroleptic (NL) therapy and after 12 and 30 days' drug withdrawal. GH peak levels after a 12-day drug-free period were significantly elevated (13.1±12 ng/ml) as compared to NL therapy (4.6±6.1 ng/ml). Controls showed a significant higher mean peak GH response (13.6±10 ng/ml) compared to chronic schizophrenic patients under long-term NL therapy. The GH response of patients with symptoms of tardive dyskinesia (TD) did not differ significantly from that of patients without signs of TD. The prolactin (PRL) serum levels under long-term NL treatment were within the normal range in male schizophrenics but decreased significantly after 12 days' drug withdrawal. The data presented indicate a reduced sensitivity of the hypothalamic-pituitary dopamine receptors under long-term NL therapy. The significant increase in GH response on day 12 probably corresponds to a readjustment from a mostly blunted GH response under NL therapy back to stimulated levels of normal controls. No supersensitivity of the pituitary dopamine recpetors could be detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00555228
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Die Phagocytoseaktivität von permanenten Fibroblasten (Monocyten), Rattenalveolarmakrophagen und menschlichen Entzündungsmakrophagen unter der Wirkung von Glucocorticoiden (1967)
    Springer
    Clinical and experimental medicine 144 (1967), S. 335-352 
    Details
    ISSN: 1591-9528
    Keywords: Glucocorticoides ; phagocytosis ; macrophages ; fibroblastes ; dust exposition ; Glucocorticoide ; Phagocytose ; Makrophagen ; Fibroblasten ; Staubexposition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Glucocorticoide hemmen die Phagocytoseaktivität von permanenten Fibroblasten und Makrophagen in vitro. In der Kultur gezüchtete Monocyten gewöhnten sich bei einer Corticoiddauerbehandlung an das veränderte Milieu, ihre anfänglich gehemmte Phagocytoseaktivität nahm wieder zu. Makrophagen aus Rattenlungen sowie menschliche Entzündungsmakrophagen zeigten nach Corticoidbehandlung eine deutliche Abnahme ihrer Phagocytoseaktivität, die bei den Rattenmakrophagen von der Dauer der Behandlung und der Dosis abhängig war. Bei Bestaubung von corticoidbehandelten Ratten konnte ebenfalls eine von der Behandlungsdauer abhängige Abnahme der Phagocytoseaktivität im Alveolarraum beobachtet werden. Bei Kurzbehandlung zeigte sich eine bimodale Wirkung des applizierten Glucocorticoids durch gesteigerte Makrophagenemigration in den Alveolarraum.
    Notes: Summary Glucocorticoides inhibit the phagocytosis activity of permanent fibroblasts and macrophages in vitro. Monocytes raised in culture become accustomed to the changed medium during a continuous corticoide treatment; their initially inhibited phagocytosis activity increased again. Macrophages from rat lungs as well as human inflammation macrophages showed after corticoide treatment a marked decrease of their phagocytosis activity dependent, in case of rat macrophages on the duration of treatment and dose. During dusting of rats treated with corticoides, there could also be observed a decrease of the phagocytosis activity in the alveolar region dependent on the duration of treatment. In case of a short treatment there was a bimodal effect of the applied glucocorticoides showed by increased macrophage emigration into the alveolar region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02043239
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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