ISSN:
1432-0428
Keywords:
Mouse
;
experimental diabetes
;
streptozotocin
;
H-2 system
;
sex hormone
;
insulitis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Five daily injections of streptozotocin (40 mg/kg) produced a delayed but progressively increasing level of hyperglycaemia in long term studies with male Naval Medical Research Institute mice and C3D2F1 (DBA 2 J male × C3H/ Tif female) F1 hybrid mice. The development of hyperglycaemia was paralleled by decreased amounts of pancreatic immunoreactive insulin as well as degranulation and necrosis of pancreatic B cells. Insulitis was found from days 9–25 after the first injection of streptozotocin. Compared with the F1 hybrid strain the parental inbred strains DBA 2 J and C3H/Tif demonstrated a certain resistance to streptozotocin. Development of hyperglycaemia did not differ in four congenic resistant lines of mice on the C57 BL/10 genetic background, indicating that major histocompatibility complex genes are not likely to determine susceptibility to streptozotocin-induced islet B cell damage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01271171
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