Electronic Resource
Springer
Psychopharmacology
32 (1973), S. 1-9
ISSN:
1432-2072
Keywords:
Sleep
;
Perlapine
;
Hypnotic
;
EEG
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Perlapine is a new hypnotic and in a pilot study of its effects on the sleep of two normal subjects 10 mg decreased intra-sleep restlessness (frequency of shifts into stage 1 sleep or wakefulness) and also decreased paradoxical sleep duration, but did not alter stages 3+4 sleep. A more extended study consisted of a baseline week, three weeks of drug and two withdrawal weeks. Three men took 10 mg and two men 20 mg of perlapine nightly. The decrease of intra-sleep restlessness and the absence of suppression of stages 3+4 were confirmed. Time spent in drowsiness and wakefulness were reduced. Paradoxical sleep was reduced in duration, with a short-lasting rebound. The 20 mg dose appeared to increase the duration of stages 3+4 sleep in the first week.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00421703
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