ISSN:
1432-0428
Keywords:
Diabetes mellitus
;
insulin
;
localised amyloidosis
;
amino acid sequence analysis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A patient with Type 1 (insulin-dependent) diabetes mellitus developed localised amyloidosis at the sites of his injections of porcine insulin. A major amyloid fibril protein was extracted and, by means of its amino acid composition and amino acid sequence, it was shown to contain intact insulin molecules. Porcine insulin is the tenth protein and the first foreign protein to be chemically identified in human amyloid fibrils.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00276849
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