ISSN:
1432-2307
Keywords:
Key words Tracheopathia osteochodroplastica
;
Bone morphogenetic protein-2
;
Transforming growth factor beta-1
;
Immunohistochemistry
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Tracheopathia osteochondroplastica (TO) is an unusual condition characterized by cartilaginous or bony submucosal nodules in the tracheobronchial tree. Bone morphogenetic protein-2 (BMP-2) and transforming growth factor beta-1 (TGF-β1) are potent inducers for new bone formation. We studied the precise localization of BMP-2 and TGF-β1 in two autopsied cases of TO, using immunohistochemical methods. Positive BMP-2 immunoreactivity was detected in numerous mesenchymal cells and chondroblasts lining the nodules in the tracheal submucosa. BMP-2 was not found in mature lamellar bony nodules. TGF-β1 was not seen in mesenchymal cells, though it did appear in chondrocytes and osteocytes in the nodules. These results suggest that BMP-2 plays an important role in nodule formation and acts synergistically with TGF-β1 to promote the nodules inductive cascade in the tracheal submucosa.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004280050111
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