ISSN:
0570-0833
Keywords:
Heterocycles
;
Intramolecular reactions
;
Acylation
;
Nitrile hydrogen halide adducts
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Five-membered, six-membered, and seven-membered aza-, diaza-, and thiazaheterocycles can be prepared by cyclization of. ω-cyano carboxylic acid halides in the presence of hydrogen halides in aprotic solvents. Nitrile-hydrogen halide adducts occur as intermediates in this novel heterocycle synthesis of wide application. The acylating cyclizations of nitriles in protonic media, which proceed via imidic esters or amides, are not discussed.
Additional Material:
9 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/anie.197301191
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