ISSN:
1432-069X
Keywords:
Polyprenoic acid derivative
;
Ornithine decarboxylase
;
Epidermis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Irradiation of skin with ultraviolet B (UVB) stimulates epidermal activity of ornithine decarboxylase (ODC), a rate limiting polyamine biosynthesing enzyme. The maximum stimulation of ODC activity by UVB was found at 24 after irradiation. Systemic administration of a polyprenoic acid derivative (E-5166) significantly inhibited the UVB-stimulated ODC activity in a dose-dependent manner. The inhibitory effect of E-5166 on the UVB-stimulated ODC activity was found to begin at 5 mg/kg body weight. These results indicate that because it inhibits ODC activity E-5166 can be utilized for the treatment of hyperproliferative skin diseases.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00418171
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