ISSN:
0749-1581
Keywords:
Captopril
;
Line-shape analysis
;
Reference deconvolution
;
Saturation transfer
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
13C NMR was used to study the cis-trans isomerization of 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) in D2O solution over the temperature range 50-100°C. Measurements of the rate of cis-trans interconversion were made by line-shape analysis and saturation transfer techniques. The combined results yielded a value for the activation energy of 89 ± 2 kJ mol-1 (21.3 ± 0.5 kcal mol-1) for the C-N bond rotation. For line-shape analysis the experimental data were treated by reference deconvolution, using a small amount of labelled acetonitrile as reference, before processing. It was found that the deconvolution process significantly improved the reliability of the analysis.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260280916
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