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  • Electronic Resource  (5)
  • Respiratory tract  (5)
  • 1
    Electronic Resource
    Electronic Resource
    Occurrence and distribution of GRP-immunoreactive nerve fibres in the respiratory tract (1984)
    Springer
    European archives of oto-rhino-laryngology and head & neck 239 (1984), S. 145-151 
    Details
    ISSN: 1434-4726
    Keywords: Gastrin releasing peptide ; Respiratory tract ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The occurrence and distribution of nerve fibres containing gastrin-releasing peptide (GRP) were investigated in the respiratory tract of several mammals using immunocytochemistry. A moderate supply of nerve fibres displaying GRP immunoreactivity was seen in the middle ear mucosa, the nasal mucosa and the tracheobronchial wall. Generally, the fibres were distributed around blood vessels and seromucous glands. In addition, scattered GRP fibres were seen in the smooth muscle of the tracheal wall. The distribution of GRP fibres in the respiratory tract suggests multiple functions of GRP such as regulation of local blood flow, glandular secretion and smooth muscle activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463555
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Neuronal galanin is widely distributed in the chicken respiratory tract and coexists with multiple neuropeptides (1989)
    Springer
    Cell & tissue research 256 (1989), S. 95-103 
    Details
    ISSN: 1432-0878
    Keywords: Respiratory tract ; Autonomic innervation ; Neuropeptide immunocytochemistry ; Galanin ; Neu-ropeptide coexistence ; Chicken
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The mammalian airways are known to be richly innervated by several types of peptide-containing nerve fibers. Galanin-containing fibers are, however, comparatively few. The results of the present immunocytochemical study indicate that the chicken airways receive a notably dense supply of galanin-storing fibers. Other major neuropeptides were neuropeptide Y, vasoactive intestinal peptide and substance P. Nerve fibers containing these peptides were distributed in the trachea, main bronchi, and the lungs. Minor nerve fiber populations contained calcitonin generelated peptide, enkephalin and gastrin-releasing peptide. In the trachea and main bronchi the majority of peptidecontaining nerve fibers was distributed beneath and sometimes also within the epithelium; fibers were fewer in the lamina propria. In the lungs they occurred both in association with the epithelium of small bronchi and in the septa. Adrenergic nerves (using tyrosine hydroxylase as marker) were predominantly distributed in the lamina propria among bundles of smooth muscle and blood vessels. In the nerve fibers associated with the epithelium and in nerve cell bodies in local ganglia of the tracheal wall, galanin was found to coexist with several other neuropeptides (neuropeptide Y, vasoactive intestinal peptide and substance P) suggesting co-expression of multiple neuropeptide genes in the same population of neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224722
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Occurrence and distribution of calcitonin gene-related peptide in the mammalian respiratory tract and middle ear (1985)
    Springer
    Cell & tissue research 241 (1985), S. 551-555 
    Details
    ISSN: 1432-0878
    Keywords: Calcitonin gene-related peptide (CGRP) ; Neuropeptide immunocytochemistry ; Respiratory tract ; Ear, middle ; Sensory innvervation ; Mammals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Nerve fibres displaying immunoreactivity to calcitonin gene-related peptide (CGRP) are abundantly distributed in the respiratory tract of man, dog, cat, guineapig, rat and mouse. Numerous fine, beaded CGRP fibres were seen in the middle ear mucosa, and a moderate supply was found in the ear drum. In the nasal mucosa and in the wall of the Eustachian tube CGRP fibres occurred around blood vessels, arteries in particular. A conspiciously rich supply of CGRP fibres was seen beneath and within the epithelium. In addition, a few fibres were seen in smooth muscle bundles and close to sero-mucous glands. In the tracheo-bronchial wall CGRP fibres were distributed beneath and within the epithelium, in vascular and non-vascular smooth muscle and sometimes close to small glands. A few CGRP-immunoreactive endocrine-like cells were, in addition, distributed in the tracheal epithelium of cat, rat and mouse. The trigeminal, spinal and nodose ganglia, studied in rats and guinea-pigs, harboured numerous CGRP-immunoreactive nerve cell bodies. The cervical sympathetic ganglia were devoid of immunoreactive neuronal perikarya. Surgical and chemical (6-hydroxydopamine treatment) sympathectomy did not affect the number and distribution of CGRP fibres. The distribution of CGRP fibres in the respiratory tract suggests that CGRP may take part in sensory transmission. In addition, CGRP may affect the regulation of local blood flow, smooth muscle tone and glandular secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214575
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Occurrence and distribution of neuropeptide-Y-immunoreactive nerves in the respiratory tract and middle ear (1984)
    Springer
    Cell & tissue research 237 (1984), S. 321-327 
    Details
    ISSN: 1432-0878
    Keywords: Neuropeptide Y ; Immunocytochemistry ; Respiratory tract ; Ear, middle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Nerve fibres displaying neuropeptide-Y (NPY) immunoreactivity are abundantly distributed in the respiratory tract of cats, guinea-pigs, rats and mice. Fine beaded NPY fibres were seen in whole-mount spreads of the middle-ear mucosa. In the nasal mucosa and in the wall of the Eustachian tube NPY fibres were numerous around arteries and arterioles but sparse in the vicinity of veins; single fibres were found close to the acini of seromucous glands. In the tracheobronchial wall NPY fibres occurred in the proximity of blood vessels, in the subepithelial layer and in the smooth muscle. Surgical and chemical (6-hydroxydopamine treatment) sympathectomy resulted in disappearance of adrenergic and NPY-containing nerve fibres in the nasal mucosa. Sequential staining with antibodies against dopamine-β-hydroxylase (DBH) and NPY revealed that DBH and NPY occur in the same perivascular nerve fibres in the nasal mucosa. The distribution of NPY fibres in the respiratory tract suggests multiple functions of NPY, such as regulation of local blood flow, glandular secretion and smooth muscle activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217151
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Chemical coding of endocrine cells of the airways: presence of helodermin-like peptides (1991)
    Springer
    Cell & tissue research 265 (1991), S. 425-433 
    Details
    ISSN: 1432-0878
    Keywords: Regulatory peptides ; Serotonin ; Protein gene product 9.5 (PGP) ; Respiratory tract ; Neuroendocrine cells ; Mouse ; Rat ; Harnster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The epithelium of the airways is rich in endocrine cells containing serotonin and/or a wide variety of regulatory peptides. These cells usually occur in clusters in the lungs but are also found scattered in the larynx and trachea. In the present study, endocrine cells in the airways of mouse, rat, hamster, guinea pig, pig, sheep and squirrel monkey were examined for the presence of serotonin, helodermin-like peptides and other regulatory peptides using immunocytochemistry and radioimmunoassay. In addition, we looked for the protein gene product 9.5 (PGP), which occurs in many peptide hormone-producing endocrine cells in the body. Both clustered and scattered endocrine cells in the airways were found to display coexistence of serotonin and peptides, such as a helodermin-like peptide, calcitonin and calcitonin gene-related peptide (CGRP). The PGP-immunoreactive cells were numerous and included elements containing serotonin and/or regulatory peptides. An additional PGP-immunoreactive endocrine cell population lacked serotonin and regulatory peptides. Helodermin-immunoreactive material was demonstrated in endocrine cells of the airways in the mouse and hamster but not in any of the other species studied. Serotonin was an endocrine cell constituent in all the species studied. Calcitonin and CGRP could be demonstrated by immunocytochemistry in the mouse, rat, and hamster, but not in the guinea pig, sheep, pig and monkey. In the hamster airways double immunostaining indicated that the helodermin-like peptide occurred in a subpopulation of the CGRP- and serotonin-containing cells. Most of the CGRP-containing cells stored serotonin; some of them also contained calcitonin. The chemical coding of these cells resembled that of the thyroid C cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00340865
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    Paper (German National Licenses)
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