ISSN:
1573-6903
Keywords:
Cocaine
;
dopamine-1 and dopamine-2 receptors
;
striatum
;
nucleus accumbens
;
WKY
;
SHR
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The characteristics of D-1 and D-2 dopamine receptors after acute and subacute cocaine administration were determined in striata and nuclei accumbens from WKY and SHR. In striata from acutely treated rats, significant increases in D-2 receptor density were observed at 30 min, 2 or 24 h following cocaine injection in both strains without changes in affinities. The density of D-1 receptors was significantly decreased 30 min after the injection in WKY, but not in SHR. In striata from subacutely treated rats, the density of D-1 receptors was significantly increased in 3- and 7-day treated WKY, but not in SHR. The affinities of both binding sites remained unchanged. In nuclei accumbens, the changes in both D-1 and D-2 receptors after cocaine administration were similar to those observed in the striatum. The results suggest that cocaine administration alters dopamine receptor binding characteristics. Furthermore, D-1 and D-2 dopamine receptors appear to be differently regulated.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00973753
Permalink
