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  • Electronic Resource  (2)
  • Time-resolved fluorescence microscopy  (2)
  • 1
    Electronic Resource
    Electronic Resource
    A 580 nm emission in haematoporphyrin-derivative solution and in treated cells (1986)
    Springer
    Lasers in medical science 1 (1986), S. 33-39 
    Details
    ISSN: 1435-604X
    Keywords: Haematoporphyrin derivative ; 580 nm emission ; Time-resolved fluorescence microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract Continuous wave and time-resolved fluorescence microscopy have been extensively used to characterize the behaviour of haematoporphyrin derivative (HPD) both in solution and in single cells. In this work, we report experimental evidence for the presence of a 580 nm-emitting species, occurring as a consequence of modifications in HPD induced by the cellular microenvironment. The fact that the formation of this ‘modified’ species seems to be favoured in tumour cells might increase sensitivity in the diagnostic use of HPD for the localization of early-stage tumours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030735
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Endocapsular lavage with photofrin II as a photodynamic therapy for lens epithelial proliferation (1990)
    Springer
    Lasers in medical science 5 (1990), S. 25-30 
    Details
    ISSN: 1435-604X
    Keywords: Haematoporphyrin derivative ; Secondary cataract ; Phaco-Ersatz ; Endocapsular surgery ; Time-resolved fluorescence microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Physics , Technology
    Notes: Abstract The most common and visually significant complication of both extracapsular and endocapsular cataract extractions is the formation of a secondary cataract because of the proliferation of retained lens epithelial cells. The intraocular distribution of Photofrin II uptake after endocapsular lensectomy and lavage has been quantified to evaluate the feasibility of photodynamic therapy to prevent proliferation. Intraocular distribution was determined by measuring the fluorescence decay curves in sections of eyes using a microspectrofluorometer with high spatial and temporal resolution. An equal affinity for lens epithelium, corneal endothelium, iris and ciliary body was noted. No significant uptake in the retina was detected. Evaluation of photodynamic therapy to prevent lens epithelial proliferation will require specific localization of the drug to lens epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032620
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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