ISSN:
0268-2605
Keywords:
butyltin
;
hydroxybenzoate ligand
;
synthesis
;
anticancer
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Six di(n-butyl)tin(IV) and two dimethyltin(IV) bis-(dihydroxybenzoate)s were synthesized and characterized by 1H, 13C and 119Sn NMR and Mössbauer spectroscopy. Five of the di(n-butyl)tin compounds were screened in vitro against six human tumour cell lines, MCF-7, EVSA-T, WiDr, IGROV, M19 and A498. They are more active than carboplatin, cisplatin and 5-fluorouracil against all cell lines and of comparable activity or better than methotrexate. All dihydroxybenzoates with an ortho-bydroxyl group are more active against MCF-7 cells than substituted salicylates screened previously.
Additional Material:
6 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aoc.590090308
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