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Microbial Production of a Crisnatol Metabolite (1992)

Hufford, Charles D. ; El-Sharkawy, Saleh H. ; Jurgens, Tannis M. ; [et al.]

Springer

Pharmaceutical research 9 (1992), S. 623-625

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ISSN: 1573-904X

Keywords: crisnatol metabolite ; crisnatol C-l3 nuclear magnetic resonance (NMR) assignments ; microbial metabolism ; two-dimensional (2D) NMR techniques

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract Microbial metabolism studies of crisnatol (1), a new DNA interca-lator, has resulted in the isolation and characterization of a major metabolite identified as the C-l hydroxylated crisnatol (2). The structure of the metabolite was established by comparison of its spectral data to that of crisnatol. Complete 13C-NMR assignments for crisnatol and its C-l hydroxylated metabolite were also made.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1015893808830

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