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  • Electronic Resource  (2)
  • fluphenazine  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Neuroleptic-induced catalepsy as a model of Parkinson's disease II. Effect of glutamate antagonists (1990)
    Springer
    Journal of neural transmission 2 (1990), S. 91-100 
    Details
    ISSN: 1435-1463
    Keywords: Catalepsy ; fluphenazine ; sulpiride ; striatum ; phencyclidine ; Parkinson's disease ; MK801 ; CPP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Subcutaneous administration of fluphenazine elicits catelepsy that can be attenuated by the glutamate antagonists MK801 and phencyclidine (PCP). 3-[-(+)-2-carboxy piperazine-4-yl]-propyl-1-phosphanate (CPP) was found to be ineffective in this model. Intrastriatal injections of sulpiride or fluphenazine were also found to induce catalepsy which could be attenuated by MK801 and PCP. These results illustrate that nondopaminergic compounds might possibly be of value in the treatment of Parkinson's disease. Furthermore it was demonstrated that this paradigm can be utilized to investigate neurotransmitter interactions within the striatum. This was clearly emphasized by the observation that bilateral administration of MK801 into the striatum increased basal locomotor activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260897
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Neuroleptic-induced catalepsy as a model of Parkinson's disease I. Effect of dopaminergic agents (1990)
    Springer
    Journal of neural transmission 2 (1990), S. 79-89 
    Details
    ISSN: 1435-1463
    Keywords: Catalepsy ; fluphenazine ; sulpiride ; striatum ; quinpirole ; Parkinson's disease ; L-DOPA ; amphetamine ; apomorphine ; SKF 38393
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Catalepsy was observed in the rat following intrastriatal injections of the dopamine antagonists sulpiride or fluphenazine and after subcutaneous administration of fluphenazine. The neuroleptic-induced catalepsy was reversed by the classical anti-parkinsonian agent L-DOPA and by agents that function through dopamine systems such as d- and methamphetamine and the direct D2 receptor agonist quinpirole. The D1 agonist SKF 38393, and the D1/D2 agonist apomorphine, were ineffective in this model. These results support limited use of the rat catalepsy model for the screening of potential anti-parkinsonian compounds and indicate that this procedure can provide valuable information concerning striatal dopamine function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02260896
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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