ISSN:
1572-994X
Keywords:
rotavirus
;
neonate
;
116E
;
nucleotide sequence
;
vaccine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We have sequenced the genes encoding the inner capsid protein VP6 and the nonstructural proteins NSP1 and NSP4 of the Indian neonatal serotype P8[11]G9 human/bovine reassortant candidate vaccine rotavirus strain 116E. These three genes share a high degree of sequence and deduced amino acid homology with human prototype strain Wa. Our results confirm and extend those of previous RNA-RNA hybridization studies which suggested that these genes are of human origin, and will facilitate examination of the host immune response to 116E induced by natural infection and vaccination.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1007958914141
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