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Digitale Medien

Variability of beta-blocker pharmacokinetics in young volunteers (1982)

Jack, D. B. ; Quarterman, C. P. ; Zaman, R. ; [weitere]

Springer

European journal of clinical pharmacology 23 (1982), S. 37-42

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Details

ISSN: 1432-1041

Schlagwort(e): metoprolol ; propranolol ; oxprenolol ; pharmacokinetics ; acetubolol ; diacetolol ; oral contraceptive

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie , Medizin

Notizen: Summary Plasma concentrations of metoprolol, propranolol oxprenolol, acebutolol and its metabolite diacetolol were measured after single oral doses in young healthy volunteers. In order to assess the inter-and intra-subject variability the following pharmacokinetic parameters were compared: AUC o 24 , Cmax, tmax and t1/2. The smallest variation in inter-subject variability was seen with oxprenolol and acebutolol: intrasubject variability was more uniform. Female volunteers taking an oral contraceptive generally had higher AUC o 24 and Cmax values than those not. This finding reached statistical significance only for metoprolol AUC o 24 .

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01061375

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