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Digitale Medien

Radioimmunoassay of human eosinophil cationic protein (ECP) by an improved method. Establishment of normal levels in serum and turnover in vivo (1991)

PETERSON, C. G. B. ; ENANDER, I. ; NYSTRAND, J. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

Clinical & experimental allergy 21 (1991), S. 0

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Details

ISSN: 1365-2222

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: A radio immunoassay was developed allowing measurement of the cytotoxic cationic ECP. The assay, which has a total incubation time of 3.5 hr, is a double antibody assay with radiolabelled ECP. covering the concentration range of 2–200 μ/l. Performance data show a detection limit of 〈 2 μg/1 and a cross-reactivity with eosinophil protein X (EPX/EDN) of 〈0.06%. The coefficient of variation (%) within the measuring range was, within assay 4.8–10.4, and total 6.6–12.0. The assay is useful for measurement in various body fluids including serum, nasal secretions and bronchoalveolar lavage fluid, and dilution of samples prior to analysts was generally not required. Sera from 100 apparently healthy individuals revealed a geometric mean of 6.0 μg ECP/1 and a range (95%) of 2.3–15.9 μg/1. The elimination rate of ECP, t12. in vivo was estimated to be 65 min when ECP was measured in serum. Comparisons between this assay and a method previously described showed that the new method is superior with regard to precision and assay procedure.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2222.1991.tb00847.x

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Digitale Medien

Methylation in the Study of Polynucleotides (1949)

ANDERSON, A. S. ; BARKER, G. R. ; FARRAR, K. R.

[s.l.] : Nature Publishing Group

Nature 163 (1949), S. 445-446

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Details

ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] ALTHOUGH detailed knowledge of the components of pentose nucleic acids is still incomplete, considerable effort over a long period has been directed towards the problem of the mode of union of the constituent nucleosides. It was early recognized that these units are linked through phosphoric ...