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  • 11
    Electronic Resource
    Electronic Resource
    EFFECTS OF ZSY-27, A SYNTHESIZED PHOSPHODIESTERASE INHIBITOR, ON EXOCRINE SECRETION AND CYCLIC NUCLEOTIDE CONCENTRATION IN THE DOG PANCREAS (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 14 (1987), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Effects of intravenous injections of ZSY-27, a synthesized phosphodiesterase inhibitor, on pancreatic exocrine secretion and on pancreatic cyclic AMP and cyclic GMP concentrations of dogs were investigated.2. ZSY-27 (0.3 and 1 mg/kg) increased cyclic AMP concentration dose-dependently, which preceded the increase in pancreatic secretion but did not affect cyclic GMP concentration.3. These results suggest that ZSY-27 causes exocrine secretion from the dog pancreas mediated through an increase in intracellular cyclic AMP concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1987.tb02428.x
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  • 12
    Electronic Resource
    Electronic Resource
    ACTIVITIES OF NAD+-DEPENDENT ALDEHYDE DEHYDROGENASE AND ALCOHOL DEHYDROGENASE IN THE LIVER OF SPONTANEOUSLY HYPERTENSIVE RATS IN THE PROCESS OF DEVELOPMENT (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 11 (1984), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The difference in the basal activities of NAD+-dependent aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) was investigated in the liver of age-matched spontaneously hypertensive (SH) and normotensive Wistar Kyoto (WK) rats.2. A significant difference between the SH and WK rats in the basal ALDH activity, ADH activity and the protein content of subcellular fractions was observed. The activities of mitochondrial low Km- and high Km-ALDH in the SH rats at 5–8 weeks of age were higher than those in the WK rats. The microsomal high Km-ALDH activity in the SH rats at 5 and 11 weeks of age was higher than that in the WK rats. The ADH activities in the SH rats at 5–14 weeks of age were lower than those in the WK rats. The mitochondrial protein content in the SH rats at 5–14 weeks of age was higher than those in the WK rats.3. At 14 weeks of age, an increase in the blood acetaldehyde level was observed after an intraperitoneal injection of 1.5 g/kg of ethanol in the SH rats. No difference in blood ethanol level was observed between the SH and WK rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1984.tb00257.x
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  • 13
    Electronic Resource
    Electronic Resource
    INHIBITORY EFFECT OF OUABAIN AND ACETAZOLAMIDE ON SECRETIN-STIMULATED PANCREATIC EXOCRINE SECRETION IN ANAESTHETIZED DOG (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 16 (1989), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of ouabain and acetazolamide on the secretion of pancreatic juice stimulated by secretin in anaesthetized dogs were investigated.2. Intra-arterial injection of ouabain (1–10 μg) and acetazolamide (1–10 mg) caused dose-dependent decreases in the volume of pancreatic juice. When both drugs were added together, the inhibitory effects were significantly higher than for each drug alone.3. The bicarbonate concentration in the pancreatic juice was decreased and the chloride concentration was increased by ouabain and acetazolamide, but sodium and protein concentrations were not modified.4. The results suggest that the Na+K+-ATPase and carbonic anhydrase activities play important roles in water and electrolyte secretion, and that ouabain and acetazolamide inhibit secretin-stimulated pancreatic secretion by acting on different systems in the exocrine cells in dogs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1989.tb01538.x
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  • 14
    Electronic Resource
    Electronic Resource
    EFFECT OF DEPLETION OF SERUM CALCIUM BY EGTA ON CANINE PANCREATIC SECRETION INDUCED BY DOPAMINE AND BY SECRETIN (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 1 (1974), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY 1. Pancreatic secretion has been monitored in the isolated, blood-perfused canine pancreas, and the effects of depletion of serum calcium by infusion of EGTA on the increases in secretion produced by intra-arterial injections of dopamine and secretin have been investigated.2. Under resting conditions in preparations in dogs fasted for 24 h, the mean rate of pancreatic secretion was 16.4 μ1/min (s. e. m. = 2, n= 12). The mean concentrations of protein, bicarbonate and chloride in the pancreatic juice were 53.8 mg/ml (s. e. m. = 4.5), 18.0 mmol/1 (s. e. m. = 1.1) and 122.5 mmol/1 (s. e. m. = 7.5), respectively. Infusion of EGTA had no effect on resting secretion.3. Secretion elicited by dopamine or secretin was diminished about 50% during the intra-arterial infusion of EGTA (10−2 mM/ml) in the perfusing blood. The protein concentration in the secretion was diminished to a similar extent. The concentrations of bicarbonate and chloride in the pancreatic juice was not modified by EGTA infusion.4. Concomitant infusion of an equimolar concentration of CaCl2 solution abolished the inhibitory effects of EGTA infusion on the secretory responses to dopamine or secretin.5. The results suggest that dopamine and secretin influence the exocrine secretions of the pancreas by actions on both acinar and ductular cells. Acinar cell secretion is more susceptible to depletion of serum calcium levels than is secretion from ductular cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1974.tb00551.x
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  • 15
    Electronic Resource
    Electronic Resource
    EFFECT OF SECRETAGOCUES ON PANCREATIC EXOCRINE SECRETION IN THE MONKEY AND THE DOG (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 12 (1985), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of secretin, cholecystokinin, dopamine, histamine and acetylcholine on the secretion of pancreatic juice were investigated in the monkey and the dog.2. In the resting state, bicarbonate concentration and the volume of pancreatic juice in the monkey were greater than those in the dog. However, the protein concentration of pancreatic juice in the monkey was less than that in the dog.3. Intravenous administration of secretin, cholecystokinin, histamine and acetylcholine caused a dose dependent increase in pancreatic secretion in both species. The responses in the monkey were greater than those in the dog. Dopamine caused pancreatic secretion only in the dog.4. The increase in bicarbonate concentrations of pancreatic juice induced by secretin and histamine in the monkey were greater than that in the dog. Increase in protein concentrations of the juice induced by cholecystokinin and acetylcholine in the monkey were less than that in the dog. However, pancreatic juice pH in both species was the same and was not affected by the secretagogues in the resting state or during the stimulation by secretogogues.5. From these results, it is concluded that there is a species difference in the secretory actions of the secretagogues in the monkey and the dog.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1985.tb00304.x
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  • 16
    Electronic Resource
    Electronic Resource
    SECRETORY AND VASCULAR EFFECTS OF THE OPTICAL ISOMERS OF NICARDIPINE (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 11 (1984), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of optical isomers of nicardipine on the secretion of pancreatic juice and blood flow were investigated in the dog-isolated, blood-perfused pancreas.2. Intra-arterial administration of (-)-nicardipine (10–300 μg) caused a dosedependent increase in pancreatic secretion. However, the (+)-isomer was much less potent than the (-)-isomer and even in 300 μg of (+)-isomer caused only a slight secretion.3. (+)- And (-)-nicardipine increased perfusion blood flow in a dose-dependent manner, and (+)-nicardipine was approximately five times as potent as the (-)-isomers. The maximum increase in a flow rate was produced by 30 μg of (+)-isomer and 100 μg of (-)-isomer.4. Bicarbonate concentration in pancreatic juice induced by (-)- and (+)-nicardipine was increased in a dose-dependent manner, but the protein concentration was only increased slightly.5. From these results, it is concluded that there is a stereoselectivity in the secretory and vascular actions of optical isomers of nicardipine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1984.tb00233.x
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  • 17
    Electronic Resource
    Electronic Resource
    EFFECTS OF 2-NICOTINAMIDOETHYL NITRATE (SG-75) ON PANCREATIC SECRETION IN THE ISOLATED, BLOOD-PERFUSED PANCREAS OF THE DOG (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 8 (1981), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of 2-nicotinamidoethyl nitrate (SG-75) on the secretion of pancreatic juice were compared with those of acetylcholine, secretin and pancreozymin in the isolated, blood-perfused dog pancreas.2. Intra-arterial administration of SG-75 (0.3-3 mg) elicited a dose-dependent increase in pancreatic secretion. Acetylcholine (10-100 μg), secretin (0.03-0.3 units) and pancreozymin (0.1-1.0 units) also elicited increased secretion.3. Secretory responses to acetylcholine were inhibited by treatment with atropine, while SG-75-, secretin-, and pancreozymin-induced secretions were not modified.4. Bicarbonate concentrations in pancreatic juice induced by SG-75 and secretin were increased in a dose-dependent manner. However, there were slight changes with acetylcholine or pancreozymin.5. Amylase activity in pancreatic juice was increased by SG-75, acetylcholine and pancreozymin, but was decreased by secretin.6. These results suggest that SG-75 stimulates pancreatic secretion by acting both on the acinar and ductular cells of the dog pancreas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1981.tb00770.x
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  • 18
    Electronic Resource
    Electronic Resource
    EFFECTS OF NICARDIPINE ON PANCREATIC EXOCRINE SECRETION IN THE DOG (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 9 (1982), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of nicardipine on the secretion of pancreatic juice were investigated in dog isolated, blood-perfused pancreas, and compared with those of papaverine, aminophylline and secretin.2. Intra-arterial administration of nicardipine (1-10 μg) elicited a dose-dependent increase in pancreatic secretion. Papaverine (0.1-1 mg), aminophylline (0.3-3 mg) and secretin (0.03-0.1 units) also elicited increased secretion. The secretory activity of nicardipine (10μg) was approximately equal to that of 0.5 mg of papaverine, 1.5 mgof aminophylline and 0.03 units of secretin.3. The concentration of bicarbonate in the pancreatic juice induced by nicardipine was increased, but the protein concentration was only increased slightly. These effects are analogous to those of secretin.4. Nicardipine-induced secretion was not modified by pretreatment with relatively large doses of phentolamine, propranolol, atropine, guanethidine, haloperidol or metiamide.5. Secretin-induced secretion was significantly potentiated by infusion of papaverine, but not by infusion of nicardipine or aminophylline.6.These results suggest that nicardipine acts on the exocrine cells in the dog pancreas, at least in part, through the increase of intracellular cyclic AMP concentration by inhibiting phosphodiesterase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1982.tb00829.x
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  • 19
    Electronic Resource
    Electronic Resource
    EFFECTS OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE IV INHIBITOR, Ro20,1724, ON PANCREATIC EXOCRINE SECRETION IN DOG (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 21 (1994), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of the cyclic nucleotide phosphodiesterase (PDE) inhibitors, Ro20,1724, 3-isobutyl-1-methylxanthine (IBMX), trifluoperazine (TFP) and amrinone on pancreatic exocrine secretion were investigated in anaesthetized dogs in comparison with those of secretin and cholecystokinin octapeptide (CCK-8).2. Ro20,1724 (1–30 nmol/kg), IBMX (3–30 nmol/kg), secretin (0.01–0.1 pmol/kg) or CCK-8 (0.1–1 pmol/kg) injected i.a. elicited a dose-dependent increase in the secretion of pancreatic juice, but TFP and amrinone (up to 1 μmol/ kg) did not.3. The bicarbonate concentration in pancreatic juice was increased and the protein concentration was decreased by Ro20,1724, IBMX and secretin. Cholecystokinin octapeptide increased the protein concentration but did not alter the bicarbonate concentration.4. Ro20,1724 and IBMX elicited more than the respective additive secretory response when added together with secretin, although the stimulatory effects of CCK-8 with Ro20,1724 and IBMX were additive.5. Ro20,1724 and IBMX increased cyclic AMP concentration but did not affect cyclic GMP concentration.6. These results suggest that Ro20,1724 and IBMX have secretory properties on pancreatic exocrine glands of the dog, which may be mediated through an increase in cyclic AMP subsequent to inhibition of PDE activity. Furthermore, pancreatic PDE enzymes in the dog may be mainly type IV.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1994.tb02573.x
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  • 20
    Electronic Resource
    Electronic Resource
    EFFECTS OF SUBSTANCE P ON PANCREATIC EXOCRINE SECRETION STIMULATED BY SECRETIN, DOPAMINE AND CHOLECYSTOKININ IN DOGS (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 13 (1986), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effect of substance P (SP) on pancreatic exocrine responses to exogenous cholecystokinin, secretin, and dopamine, were studied in the isolated and blood-perfused pancreas of dogs.2. Intra-arterial injection of SP had a significant biphasic effect on pancreatic secretion: an initial transient inhibition, followed by an increase in the secretion stimulated by the infusion of cholecystokinin. However, SP caused only an inhibition of secretion stimulated by the infusion of secretin and dopamine.3. SP increased protein concentration but not bicarbonate concentration in juice stimulated by cholecystokinin, but SP did not affect significantly either protein or bicarbonate concentrations in juice stimulated by secretin and dopamine.4. These results suggest that SP has greater effects on the pancreatic secretion stimulated by cholecystokinin than that stimulated by secretin and dopamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1986.tb02395.x
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