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  • 11
    Electronic Resource
    Electronic Resource
    Treatment of advanced hormone-refractory prostate carcinoma with a combination of etoposide, pirarubicin and cisplatin (1994)
    Springer
    Cancer chemotherapy and pharmacology 35 (1994), S. 225-229 
    Details
    ISSN: 1432-0843
    Keywords: Key words Prostate cancer ; Hormone-refractory prostate carcinoma ; EAP regimen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A total of 20 patients with hormone-refractory prostate carcinoma entered a pilot study of combination chemotherapy based on the EAP (etoposide, Adriamycin and cisplatin) regimen, in which Adriamycin was replaced by pirarubicin, a less cardiotoxic derivative of Adriamycin. The response was assessed by criteria modified from those of the National Prostatic Cancer Project: prostate-specific antigen was employed instead of acid phosphatase. Of 18 evaluable patients, 6 achieved a partial response, 5 had stable disease, and in 7 the disease had progressed during therapy; thus, the overall response rate was 33.3% [95% confidence interval (CI) 11.5–55.1%]. Significant pain alleviation and performance status improvement were obtained in 5 of 12 patients (41.7%; CI 13.8–69.6%) and 3 of 13 patients (23.1%; CI 0.2–46.0%), respectively. Although myelosuppression was moderate to severe, no chemotherapy-related deaths or bacteriologically documented sepsis occurred; nor was there any clinical cardiotoxicity. All the responding patients received maintenance chemotherapy with etoposide thereafter. At present, the median duration of response is 33 weeks (range: 23–91 weeks) and the median survival period for all patients is 42 weeks (range: 27+ –136 weeks), with 12 deaths. In spite of the small number of patients treated, these results suggest that this chemotherapy regimen is active in advanced hormone-refractory prostate carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686552
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  • 12
    Electronic Resource
    Electronic Resource
    Treatment of advanced hormone-refractory prostate carcinoma with a combination of etoposide, pirarubicin and cisplatin (1995)
    Springer
    Cancer chemotherapy and pharmacology 35 (1995), S. 225-229 
    Details
    ISSN: 1432-0843
    Keywords: Prostate cancer ; Hormone-refractory prostate carcinoma ; EAP regimen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A total of 20 patients with hormone-refractory prostate carcinoma entered a pilot study of combination chemotherapy based on the EAP (etoposide, Adriamycin and cisplatin) regimen, in which Adriamycin was replaced by pirarubicin, a less cardiotoxic derivative of Adriamycin. The response was assessed by criteria modified from those of the National Prostatic Cancer Project: prostate-specific antigen was employed instead of acid phosphatase. Of 18 evaluable patients, 6 achieved a partial response, 5 had stable disease, and in 7 the disease had progressed during therapy; thus, the overall response rate was 33.3% [95% confidence interval (CI) 11.5–55.1%]. Significant pain alleviation and performance status improvement were obtained in 5 of 12 patients (41.7%; CI 13.8–69.6%) and 3 of 13 patients (23.1%; CI 0.2–46.0%), respectively. Although myelosuppression was moderate to severe, no chemotherapy-related deaths or bacteriologically documented sepsis occurred; nor was there any clinical cardiotoxicity. All the responding patients received maintenance chemotherapy with etoposide thereafter. At present, the median duration of response is 33 weeks (range: 23–91 weeks) and the median survival period for all patients is 42 weeks (range: 27+ −136 weeks), with 12 deaths. In spite of the small number of patients treated, these results suggest that this chemotherapy regimen is active in advanced hormone-refractory prostate carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686552
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  • 13
    Electronic Resource
    Electronic Resource
    The dipstick test in the diagnosis of UTI and the effect of pretreatment catheter exchange in catheter-associated UTI (1992)
    Springer
    Infection 20 (1992), S. S157 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir untersuchten den Nutzen des Eintauchteststreifens zur Ermittlung einer Leukozyturie und Bakteriurie für die Diagnosestellung einer Harnwegsinfektion (HWI). Der Esterase-Streifentest läßt sich schnell durchführen; damit kann die Leukozytenesterase sehr leicht im Urin festgestellt werden. Der Nitrit- Streifentest zur Ermittlung einer Bakteriurie korrelierte dagegen sehr schlecht mit den Ergebnissen der Urinkultur. Daraus ergibt sich, daß der Esterase-Teststreifen zur Ermittlung einer Leukozyturie im Gegensatz zum Nitrit-Streifentest bei der Diagnosestellung einer HWI nützlich ist. Katheter-bedingte HWI sind die am schwierigsten zu behandelnden Gruppen von HWI. Einer der Gründe dafür ist die Bildung von Biofilm auf der Katheteroberfläche. Wir untersuchten die Wirksamkeit des Katheterwechsels unmittelbar vor Therapiebeginn einer Katheter-bedingten HWI, wobei zur Therapie 300 oder 600 mg/Tag Levofloxacin, eines der neueren Chinolone, verwendet wurde. Wir konnten jedoch keinen Einfluß dieser Maßnahme auf die Medikamentenwirksamkeit nachweisen.
    Notes: Summary We examined the value of the dipstick test for detecting pyuria and bacteriuria in the diagnosis of urinary tract infection (UTI). The dipstick esterase test could be quickly assessed and could easily detect leukocyte esterase in the urine. This was well correlated with the conventional sedimentation method. The dipstick nitrate reduction method for detecting bacteriuria, however, was not well correlated with the urine culture method. These findings suggested that the dipstick esterase test was a useful method for detecting pyuria in the diagnosis of UTI, but not the dipstick nitrate reduction method. Catheter-associated UTI is the most difficult category of UTI to treat and control. One of the reasons for this is the formation of biofilm around the indwelling catheter. We attempted to evaluate the effect of catheter exchange just before treatment of catheter-associated UTI with either 300 or 600 mg/day of levofloxacin, one of the newer quinolones. However, we are unable to find any apparent effect on the drug's efficacy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01704360
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  • 14
    Electronic Resource
    Electronic Resource
    Clinical superinfection in complicated urinary tract infections: Therapy with broad-spectrum beta-lactam antibiotics in urology (1985)
    Springer
    Infection 13 (1985), S. S96 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In kontrollierten Phase III-Studien werden derzeit in Japan neue, in der Entwicklung befindliche Antibiotika verglichen. Da auf eine möglichst weitgehende Übereinstimmung der demographischen Daten der Patienten, der Dosierung und Behandlungsdauer geachtet wurde, können die Ergebnisse der Studien zur Beurteilung der Eigenschaften der neuen Antibiotika herangezogen werden. Die meisten Patienten, bei denen klinische Superinfektionen auftreten, leiden an Krankheiten der Harnwege, auf die sich komplizierte Harnwegsinfektionen aufpfropfen. Die Beseitigung oder Besserung dieser Grundkrankheiten ist die Voraussetzung dafür, daß klinische Superinfektionen vermieden werden können. Unter den Mikroorganismen, die vorwiegend nach Behandlung mit Breitspektrum-Beta-Lactam-Antibiotika klinische Superinfektionen auslösen können, sind Enterokokken,Pseudomonas aeruginosa, Pseudomonas spp. und Pilze. Enterokokken finden sich häufig bei Patienten mit Mischinfektionen, sie sind durch Wechsel der Antibiotika leicht zu beseitigen.
    Notes: Summary In Japan, new antibiotics under development are compared with conventional antibiotics in Phase III controlled studies. Since the patients' demographic data, dosage, treatment period, etc. are made as uniform as possible in these studies, the results obtained are suitable for evaluating the characteristics of the new antibiotics. Most patients developing clinical superinfections suffer from complicated urinary tract infections due to underlying diseases. In order to avoid clinical superinfections, clinicians have to try to eradicate or alleviate these underlying diseases. The predominant microorganisms that may cause clinical superinfections to develop following therapy with broad-spectrum beta-lactam antibiotics include enterococci,Pseudomonas aeruginosa, otherPseudomonas spp. and fungi. Enterococci may frequently be detected in patients with mixed infections and can easily be dealt with by changing the antibiotics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01644227
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  • 15
    Electronic Resource
    Electronic Resource
    Proposals regarding guidelines for the evaluation of new antibacterial drugs for the treatment of UTI in children (1994)
    Springer
    Infection 22 (1994), S. S8 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01716026
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  • 16
    Electronic Resource
    Electronic Resource
    Infectious Complications of Combination Anticancer Chemotherapy for Urogenital Cancers (1999)
    Springer
    International urology and nephrology 31 (1999), S. 7-14 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We reviewed the infectious complications in 207 courses of anticancer chemotherapy to 93 patients with urogenital cancer. Thirty episodes (14.5%) of neutropenic fever containing 9 cases (4.3%) of infection were observed. Five patients (16.7%) had pyelonephritis, one (3.3%) had acute prostatitis, two (6.6%) had pneumonia and one (3.3%) had bacteraemia. Multivariate analysis revealed that the infectious complications during anticancer chemotherapy were mainly associated with urinary diversion, hydronephrosis and duration of severe neutropenia (〈500/mm3). These results suggest that infectious complications should be prevented in patients with urinary diversion, hydronephrosis and severe neutropenia during anticancer chemotherapy for urogenital cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007107403610
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  • 17
    Electronic Resource
    Electronic Resource
    Sparfloxacin in the treatment of males with urethritis (1992)
    Springer
    European journal of clinical microbiology & infectious diseases 11 (1992), S. 660-660 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01961679
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