Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Electronic Resource
    Electronic Resource
    Statistical evaluation of molecular descriptors and quantitative structure-property relationship studies of retinoids
    Amsterdam : Elsevier
    Journal of Pharmaceutical and Biomedical Analysis 12 (1994), S. 867-874 
    Details
    ISSN: 0731-7085
    Keywords: Cluster analysis ; factor analysis ; molecular descriptors ; quantitative structure-property relationship (QSPR) ; regression analysis ; retinoids ; topological indices.
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0731-7085(94)E0021-R
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    Plasma fibronectin concentrations in blood products (1990)
    Springer
    Intensive care medicine 16 (1990), S. 41-43 
    Details
    ISSN: 1432-1238
    Keywords: Fibronectin ; Blood products ; Mononuclear phagocyte system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Plasma fibronectin is an important opsonic protein of the mononuclear phagocyte system (MPS). In this study, plasma fibronectin concentrations were measured in stored and fresh whole blood, fresh frozen plasma and AGH cryoprecipitate. Stored whole blood had the lowest concentrations (151±50 mg/l). The concentrations in fresh whole blood plasma (227±66 mg/l) and fresh frozen plasma (224±78 mg/l) were similar but significantly higher than in stored whole blood (p〈0.05). In contrast, AHG cryoprecipitate had the highest fibronectin concentrations (3249±502 mg/l) (p〈0.001). In correcting fibronectic deficiency the best results can thus be expected from an infusion of cryoprecipitate, but fresh whole blood and fresh frozen plasma may also increase depressed fibronectin levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01706323
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    Propofol emulsion reduces proliferative responses of lymphocytes from intensive care patients (1993)
    Springer
    Intensive care medicine 19 (1993), S. 299-302 
    Details
    ISSN: 1432-1238
    Keywords: Anesthetics ; Propofol ; Fat emulsion ; Lymphocyte transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To test propofol lipid emulsion formulation for its immunosuppressive effects. Design Propofol lipid emulsion and the emulsion alone were tested at increasing concentrations and compared to initial values and between each other. Propofol alone could not be tested due to its insolubility into the culture medium. Patients and participants Lymphocytes from 12 surgical intensive care (ICU) patients (median APACHE score 16 and median TISS score 28) and 12 healthy volunteers. Measurements Phytohaemagglutinin-, concanavalin A-and pokeweed mitogen-induced lymphocyte proliferative responses were measured in the presence of increasing concentrations of propofol lipid emulsion formulation or the lipid emulsion. Results Lymphocyte proliferative responses from ICU patients were in general on a lower level than in the volunteers. The propofol lipid emulsion formulation (Diprivan®) decreased pokeweed mitogen-induced proliferative responses of lymphocytes from ICU patients at propofol concentrations found in the circulation (1–10 μg/ml) and the lipid emulsion alone at 100 μg/ml triglyceride concentrations while the other mitogen-induced responses were not affected. No changes were observed in the mitogen-induced responses of lymphocytes from healthy volunteers. Conclusions Propofol emulsion formulation decreased in surgical intensive care patients pokeweed mitogen-induced lymphocytic responses in vitro at clinically found concentrations, indicating the need for further studies to test B-lymphocyte functions and T-B-lymphocyte co-operation during propofol lipid emulsion administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01690552
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    CSF penetration and pharmacokinetics of midazolam (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 247-251 
    Details
    ISSN: 1432-1041
    Keywords: midazolam ; CSF penetration ; pharmacokinetics ; benzodiazepines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The passage of midazolam, a new benzodiazepine derivative with highly water-soluble salts, into cerebrospinal fluid (CSF) was studied after a single oral dose of 15 mg (n=23), a single i.m. injection of 0.075 or 0.150 mg/kg (n=8), or a single i.v. dose of 0.075 mg/kg (n=26). Contrary to previous studies of diazepam and flunitrazepam, the rapid clinical effect of midazolam cannot be explained by rapid passage into human lumbar CSF. In only four cases following intravenous injection was there a measurable amount of drug in lumbar CSF (lower limit of assay sensitivity=2 ng/ml). After both oral (n=10) and intramuscular (n=8) administration, midazolam was rapidly absorbed, with attainment of the peak serum level after about 0.5 h. The pharmacokinetic parameters following i.v. injection of midazolam (n=6) explain its rapid but brief duration of action.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543799
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 15
    Electronic Resource
    Electronic Resource
    Apolipoprotein E phenotypes and plasma lipids in diabetic children and adolescents (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 564-568 
    Details
    ISSN: 1432-1076
    Keywords: Type I diabetes ; Apolipoprotein E ; Serum lipids ; Apolipoprotein B
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Apolipoprotein E (apoE) polymorphism is a genetic determinant of serum lipoprotein levels and coronary heart disease risk. ApoE appears in three major isoforms E2, E3 and E4, coded by corresponding alleles ε2, ɛ3 and ɛ4. These give six different phenotypes. Patients with insulin dependent diabetes (IDDM) have been reported to have increased incidence of E2/2 homozygosity. We studied the frequencies of apoE phenotypes and their association with plasma lipids in 201 diabetic children, aged 2–17 years, and in 216 healthy controls with the same age range. Phenotyping was performed directly from plasma by iso-electric focusing and immunoblotting. Plasma total and high density lipoprotein (HDL) cholesterol (C) and triglycerides were determined by routine laboratory methods. Apolipoprotein A1 (apoA1) and B (apoB) were measured by turbidometry. There were no differences in apoE phenotype or allele distributions between the diabetic and control subjects. The frequencies of ɛ2, ɛ3, and ɛ4 in the diabetic and control children were 0.08 versus 0.07, 0.73 versus 0.72 and 0.19 versus 0.21. The difference in apoE2/2 frequencies (2.0 in diabetic and 0.5% in normal children) was not statistically significant. In the diabetic children, there was a distinct relation between apoE phenotype and plasma lipids; presence of apoE2 was associated with the lowest and that of apoE4 with the highest concentrations of total and low density lipoprotein (LDL) C, and apoB. Ratios of HDL-C/LDL-C and apoA1/apoB showed on opposite trend. The influence of apoE polymorphism on plasma lipids was less clear in the controls. ApoE polymorphism did not relate to body mass index, glycohaemoglobin A1c or daily insulin dosage. As compared to controls, diabetic children had significantly lower concentrations of total and LDL-C and apoB as well as higher ratios of HDL-C/LDL-C and apoA1/apoB. In conclusion, there was no difference in distribution of apoE phenotypes or alleles between diabetic and non-diabetic children. ApoE polymorphism proved to be an important genetic determinant of plasma lipid levels in patients with IDDM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954081
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 16
    Electronic Resource
    Electronic Resource
    Effect of the organic modifier on the retention of retinoids in reversed-phase liquid chromatography (1993)
    Springer
    Chromatographia 36 (1993), S. 147-151 
    Details
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Polarity ; Retinoids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The retention of retinoids in reversed-phase liquid chromatography was studied using aqueous mobile phases of different composition (methanol 94–86% and acetonityrile 92–82%) at five temperatures (40–60 °C). With both organic modifiers the effect of the molecular structure increased as the water content and the polarity of the mobile phase increased. The temperature-dependence increased in the same manner with aqueous acetonitrile mobile phases. The π-π interactions between the retinoids and acetonitrile diminish when the water content of the mobile phase is increased, as happens also to the hydrophobic interactions with both organic modifiers. The net effect of these changes depends on the composition of the mobile phase. There was excellent correlation of retention with all polarity parameters studied(ϕ, P′, xe, xd, xn, E T N , δT, δ, δo and δd), when the calculations were made separately with methanol and acetonitrile. The volume fraction of the organic modifier, ϕ, was the only parameter describing the retention well in both organic modifiers simultaneously.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02263852
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 17
    Electronic Resource
    Electronic Resource
    Effect of nonstationary temperature field on stress-intensity factors of a transversally isotropic body with a crack (1976)
    Springer
    Materials science 11 (1976), S. 437-441 
    Details
    ISSN: 1573-885X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00715448
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 18
    Electronic Resource
    Electronic Resource
    Retention of retinoids on an aromatic stationary phase in reversed-phase liquid chromatography (1993)
    Springer
    Chromatographia 37 (1993), S. 501-504 
    Details
    ISSN: 1612-1112
    Keywords: π-π interactions ; Mobile phase effects ; Phenyl stationary phase ; Retinoids ; Temperature effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The retention behaviour of retinoids, which are π-electron containing solutes, on a phenyl stationary phase was studied using mobile phases consisting of aqueous methanol (MeOH; 76–84 % v/v) and acetonitrile (ACN; 60–82% v/v) at five temperatures (40–60°C). Retention was increasingly affected in both mobile phases by temperature and molecular structure with increasing water content. The effects of mobile-phase are stronger in MeOH and highly aqueous ACN, retention is enhanced. The π-π interactions have a significant effect on the selectivity of chromatographic separations when the sample compounds differ in their electron donor/acceptor capacities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02275787
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...