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  • 11
    Electronic Resource
    Electronic Resource
    Synthetic arterial grafts cause prolonged increase in the in vivo formation of thromboxane and prostacyclin in humans (1987)
    Springer
    Research in experimental medicine 187 (1987), S. 175-184 
    Details
    ISSN: 1433-8580
    Keywords: Thromboxane ; Prostacyclin ; Metabolites ; Synthetic arterial grafts ; Humans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate the in vivo production of thromboxane A2 and prostacyclin their major urinary metabolites were measured in patients following graft replacement of the abdominal aorta. Specific methods based on gas chromatography-mass spectrometry were used to measure the urinary excretion of 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1α. The excretion of these metabolites increased tenfold and almost fortyfold during post-operative Day 1 and remained elevated 6–10 days p.o. In a group undergoing cholecystectomy smaller changes of shorter duration were seen. It is concluded from this study that synthetic grafts cause prolonged increase in the in vivo formation of thromboxane A2 and prostacyclin. The reason for the increased TxA2 formation is probably platelet interaction with the foreign surface, whereas the increase of PGI2 could be part of a vascular defense against induced thrombotic activity. Those increases may have pathophysiologic implications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852081
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    The prostaglandin-analogue-9-deoxo-16,16-dimethyl-9-methylene-PGE2 inhibits the antidiuretic effect of vasopressin (AVP) in the conscious sheep (1984)
    Springer
    Pflügers Archiv 402 (1984), S. 360-363 
    Details
    ISSN: 1432-2013
    Keywords: Prostaglandin ; Analogue ; Anti-AVP ; Water diuresis ; Conscious sheep
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of intravenous infusions of the stable prostaglandin analogue 9-deoxo-16,16-dimethyl-9-methylene-PGE2 (9-methylene-PGE2) in a dosage of 10 or 24 μg/min were studied in the consicious euhydrated, dehydrated, and hyperhydrated with the simultaneous administration of exogenous arginine vasopressin (AVP), sheep. The infusions decreased urine osmolality and increased urine flow and renal free water clearance. The results indicate that 9-methylene-PGE2 exhibits its diuretic effect by antagonizing the antidiuretic action of AVP. In the hyperhydrated sheep receiving AVP the syndrome of inappropriate antidiuretic hormone release (SIADH) was simulated. As the prostaglandin analogue effectively blocked the antidiuretic effect of the AVP-administration it appears that 9-methylene-PGE2 may play a future role as a diuretic agent, especially in conditions characterized by water retention and dilutional hyponatremia such as SIADH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00583936
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    Paper (German National Licenses)
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  • 13
    Electronic Resource
    Electronic Resource
    Rapid recovery of in vivo prostacyclin formation after inhibition by aspirin (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 69-73 
    Details
    ISSN: 1432-1041
    Keywords: acetylsalicylic acid ; prostacyclin formation ; thromboxane A2 formation ; GC-MS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of aspirin on the in vivo formation of prostacyclin and thromboxane A2 in normal healthy individuals was studied by measuring the urinary excretion of 2,3-dinor-6-keto-PGF1α and 2,3-dinor-TxB2 by gas chromatography-mass spectrometry. Administration of 500 mg aspirin twice daily caused a sustained reduction in the excretion of 2,3-dinor-TxB2 to 10–15% of the predose value, while the excretion of 2,3-dinor-6-keto-PGF1α was reduced for only about 3 hours after the aspirin dose. The data demonstrate a considerable difference in the inhibitory effect of aspirin on the in vivo synthesis of thromboxane A2 and prostacyclin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614198
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    Paper (German National Licenses)
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  • 14
    Electronic Resource
    Electronic Resource
    Effects of naproxen on the in vivo synthesis of thromboxane and prostacyclin in man (1989)
    Springer
    European journal of clinical pharmacology 37 (1989), S. 563-565 
    Details
    ISSN: 1432-1041
    Keywords: naproxen ; thromboxane synthesis ; prostacyclin synthesis ; cyclooxygenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of a single oral dose of 500 mg naproxen on the synthesis in vivo of thromboxane A2 and prostacyclin was studied in healthy volunteers. The synthesis of the prostanoids was assessed by measuring the urinary excretion of the metabolites 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1α, respectively, using stable isotope dilution assays based on gas chromatography — mass spectrometry. Naproxen caused significant inhibition of the excretion of both metabolites for about two days. The reduction of the thromboxane metabolite was more pronounced (75% inhibition) than that of the prostacyclin metabolite (about 50% inhibition). The data support the idea that naproxen causes reversible inhibition of cyclooxygenase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562545
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    Paper (German National Licenses)
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