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  • 1
    Electronic Resource
    Electronic Resource
    Collagen content and collagen extractability pattern of adult human trabecular bone according to age, sex and amount of bone mass
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 244 (1971), S. 410-420 
    Details
    ISSN: 0304-4165
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-4165(71)90243-1
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  • 2
    Electronic Resource
    Electronic Resource
    Studies on EDTA extracts and collagenase digests from osteoporotic cancellous bone of the femoral head
    Amsterdam : Elsevier
    Clinical Biochemistry 20 (1987), S. 221-224 
    Details
    ISSN: 0009-9120
    Keywords: bone matrix ; femur head ; osteoporosis
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0009-9120(87)80124-8
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Radiological prevalence of lumbar intervertebral disc calcification in the elderly: an autopsy study (1996)
    Springer
    Skeletal radiology 25 (1996), S. 231-235 
    Details
    ISSN: 1432-2161
    Keywords: Key words Intervertebral disc calcification ; Osteoarthritis ; Radiographs ; Computed tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Objective. The objective of this study was to investigate the in vitro radiological prevalence of lumbar intervertebral disc calcification (IDC) in the elderly and its relation to osteoarthritis (OA). Materials and methods. Lumbar spine segments comprising L2–4 were resected from 60 cadavers (30 males, 30 females; average age 67 years) and investigated with high-contrast radiography and computed tomography (CT). Results and conclusions. IDC was found in 58.3% of the patients using high-contrast radiography and in 46.7% of the patients using CT. IDC prevalence and OA grades in the lumbar spine and right hand were found to increase with age. IDC prevalence and OA grades for L2–3 were not significantly different from those for L3–4. No significant sex difference was found for IDC prevalence and OA grades. The results indicate that IDC is significantly underestimated in vivo by conventional radiography and that intervertebral disc calcification may be a common phenomenon in aging. The exact relation of IDC to OA remains undetermined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050070
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  • 4
    Electronic Resource
    Electronic Resource
    Osteopathia striata and focal dermal hypoplasia (1979)
    Springer
    Skeletal radiology 4 (1979), S. 223-227 
    Details
    ISSN: 1432-2161
    Keywords: Osteopathia striata ; Voorhoeve's disease ; Congenital bone disease ; Ecto-mesodermal dysplasia ; Focal dermal hypoplasia ; Goltz syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 43-year old female, presenting with pain in the left knee, attributed to a stress fracture of the tibia, was found to have osteopathia striata and numerous other congenital anomalies, not only of the skeleton, but also of other tissue systems. Of the latter the most important was the presence of focal dermal hypoplasia, a disorder of the skin. Review of the radiological and dermatological literature has shown this to be the fourteenth case in which these excessively rare entities have been associated. Such an association is considered to be more than a coincidence. A radiological diagnosis of osteopathia striata, therefore, should be followed by a careful dematological examination for focal dermal hypoplasia. Conversely, diagnosis of this rare dermatological disease should indicate the necessity for radiological survey of the skeleton.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347218
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  • 5
    Electronic Resource
    Electronic Resource
    Measurements of vertebral shape by radiographic morphometry: sex differences and relationships with vertebral level and lumbar lordosis (1998)
    Springer
    Skeletal radiology 27 (1998), S. 380-384 
    Details
    ISSN: 1432-2161
    Keywords: Key words Vertebral morphometry ; Lumbar lordosis angle ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Objective. To examine sex-related and vertebral-level-specific differences in vertebral shape and to investigate the relationships between the lumbar lordosis angle and vertebral morphology. Design and patients. Lateral thoracic and lumbar spine radiographs were obtained with a standardized protocol in 142 healthy men and 198 healthy women over 50 years old. Anterior (Ha), central (Hc) and posterior (Hp) heights of each vertebra from T4 to L4 were measured using a digitizing technique, and the Ha/Hp and Hc/Hp ratios were calculated. The lumbar lordosis angle was measured on the lateral lumbar spine radiographs. Results. Ha/Hp and Hc/Hp ratios were smaller in men than women by 1.8% and 0.7%, respectively, and these ratios varied with vertebral level. Significant correlations were found between vertebral shape and the lumbar lordosis angle. Conclusions. These results demonstrate that vertebral shape varies significantly with sex, vertebral level and lumbar lordosis angle. Awareness of these relationships may help prevent misdiagnosis in clinical vertebral morphometry.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002560050402
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  • 6
    Electronic Resource
    Electronic Resource
    Letter (1996)
    Springer
    Osteoporosis international 6 (1996), S. 183-184 
    Details
    ISSN: 1433-2965
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01623945
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  • 7
    Electronic Resource
    Electronic Resource
    Population-based geographic variations in dxa bone density in Europe: The evos study (1997)
    Springer
    Osteoporosis international 7 (1997), S. 175-189 
    Details
    ISSN: 1433-2965
    Keywords: Aging ; Bone densitometry ; Epidemiology ; European Spine Phantom ; Geographic variation ; Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was to investigate variations in bone density between 16 European populations, 13 of which were participants in the European Vertebral Osteoporosis Study (EVOS). Men and women aged 50–80 years were recruited randomly from local population registers, stratified in 5-year age bands. The other three centres recruited similarly. Random samples of 20–100% of EVOS subjects were invited for dual-energy X-ray absorptiometry (DXA) densitometry of the lumbar spine and/or proximal femur using Hologic, Lunar or Norland pencil beam machines or, in one centre, a Sopha fan-beam machine. Cross-calibration of the different machines was undertaken using the European Spine Phantom prototype (ESPp). Highly significant differences in mean bone density were demonstrated between centres, giving rise to between-centre SDs in bone density that were about a quarter of a population SD. These differences persisted when centres using Hologic machines and centres using Lunar machines were considered separately. The centres were ranked differently according to whether male or female subjects were being considered and according to site of measurement (L2–4, femoral neck or femoral trochanter). As expected, bone mineral density (BMD) had a curvilinear relationship with age, and apparent rates of decrease slowed as age advanced past 50 years in both sexes. In the spine, not only did male BMD usually appear to increase with age, but there was a highly significant difference between centres in the age effect in both sexes, suggesting a variability in the impact of osteoarthritis between centres. Weight was consistently positively associated with BMD, but the effects of height and armspan were less consistent. Logarithmic transformation was needed to normalize the regressions of BMD on the independent variates, and after transformation, all sites except the femoral neck in females showed significant increases in SD with age. Interestingly, the effect of increasing weight was to decrease dispersion in proximal femur measurements in both sexes, further accentuating the tendency in women for low body mass index to be associated with osteoporosis as defined by densitometry. It is concluded that there are major differences between BMD values in European population samples which, with variations in anthro-pometric variables, have the potential to contribute substantially to variations in rates of osteoporotic fracture risk in Europe.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01622286
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  • 8
    Electronic Resource
    Electronic Resource
    Studies on EDTA extracts and collagenase digests from osteoporotic cancellous bone of the femoral head
    Amsterdam : Elsevier
    Clinical Biochemistry 20 (1987), S. 221-224 
    Details
    ISSN: 0009-9120
    Keywords: bone matrix ; femur head ; osteoporosis
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0009-9120(87)80124-8
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of Salmon Calcitonin on Femoral Bone Quality in Adult Ovariectomized Ewes (1996)
    Springer
    Calcified tissue international 59 (1996), S. 315-320 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Ewe — Ovariectomy — Calcitonin — Bone quality — Crystallography.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. The aim of this study was to evaluate the effect of intermittent calcitonin on femoral bone quality in adult ewes from the time of ovariectomy. Six months after the start of the experiment, bone density measurements and mechanical testing (torsion and resonant frequency analysis of the diaphysis and compression of an excised trabecular bone cylinder from the femoral neck) were performed in sham-control and ovariectomized (OVX) ewes treated with placebo or salmon calcitonin (50 or 100 units, 3 times/week). Crystallinity of bone was evaluated by measuring X-ray diffraction line broadening. After OVX, a nonsignificant bone loss was found at all measured sites in the femur (−3 to −9%) together with a decreased biomechanical competence in the trabecular bone (compressive strain −28%, P 〈 0.05). Treatment with salmon calcitonin, 50 or 100 IU subcutaneously three times a week from the time of ovariectomy, resulted in a significant dose-dependent preservation of bone strength in the trabecular bone of the femoral neck compared with OVX. No adverse effects of calcitonin were observed on bone crystal composition as assessed by diffractiometry. We conclude that in adult ewes intermittent calcitonin treatment from the time of OVX was associated with a significant preservation of cancellous bone strength and strain in trabecular bone of the femoral neck, without affecting crystalline properties of bone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900132
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  • 10
    Electronic Resource
    Electronic Resource
    Lack of In Vitro Evidence for Storage of 1,25-Dihydroxycholecalciferol (1,25(OH)2D3) and 1,25(OH)2D3 Binding Protein in Skeletal Matrix (1996)
    Springer
    Calcified tissue international 59 (1996), S. 488-491 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Vitamin D — Bone matrix — Osteocalcin — IGF-I.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. A few studies have reported on the measurement of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) in bone, using chloroform/methanol extraction and radioreceptor assay. As the significance of bone 1,25(OH)2D3 content was not defined in any of these reports, the objective of the current investigation was to determine whether 1,25(OH)2D3 may be stored in skeletal matrix. Bone powder samples from the iliac crest were extracted in ethylacetate/cyclohexane and 1,25(OH)2D3 isolated from the extract by means of Sephadex LH-20 and high pressure liquid chromatographic separation and subsequently measured by radioimmunoassay (RIA). Within the detection range of the RIA, no 1,25(OH)2D3 could be measured, suggesting that 1,25(OH)2D3 is not stored in skeletal matrix. Vitamin D bone concentrations previously measured may therefore have reflected plasma contamination. Consistent with this hypothesis, only traces of skeletal 1,25(OH)2D3 binding protein were measured when compared with serum values. Although 1,25(OH)2D3 may act as a potential local determinant of bone remodeling, there is no evidence supporting a delayed paracrine function by matrix-derived 1,25(OH)2D3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369215
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