ISSN:
1432-1041
Keywords:
metoprolol
;
propranolol
;
oxprenolol
;
pharmacokinetics
;
acetubolol
;
diacetolol
;
oral contraceptive
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Plasma concentrations of metoprolol, propranolol oxprenolol, acebutolol and its metabolite diacetolol were measured after single oral doses in young healthy volunteers. In order to assess the inter-and intra-subject variability the following pharmacokinetic parameters were compared: AUC o 24 , Cmax, tmax and t1/2. The smallest variation in inter-subject variability was seen with oxprenolol and acebutolol: intrasubject variability was more uniform. Female volunteers taking an oral contraceptive generally had higher AUC o 24 and Cmax values than those not. This finding reached statistical significance only for metoprolol AUC o 24 .
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01061375
Permalink
