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  • 1
    Electronic Resource
    Electronic Resource
    Tissue Distribution, Autoradiography, and Metabolism of 4-(2′-Methoxyphenyl)-1-[2′ -[N-2″-Pyridinyl)-p-[18F]Fluorobenzamido]ethyl]piperazine (p-[18F]MPPF), a New Serotonin 5-HT1A Antagonist for Positron Emission Tomography (2000)
    Oxford UK : Blackwell Science Ltd.
    Journal of neurochemistry 75 (2000), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The in vivo behavior of 4-(2′-methoxyphenyl)-1-[2′-[N-(2″-pyridinyl)-p-[18F]fluorobenzamido]ethyl]-piperazine (p-[18F]MPPF), a new serotonin 5-HT1A antagonist, was studied in awake, freely moving rats. Biodistribution studies showed that the carbon-fluorine bond was stable in vivo, that this compound was able to cross the blood-brain barrier, and that a general diffusion equilibrium could account for the availability of the tracer. The great quantity of highly polar metabolites found in plasma did not contribute to the small amounts of metabolites found in hippocampus, frontal cortex, and cerebellum. Exvivo p-[18F]MPPF and in vitro 8-hydroxy-2-(di-n-[3H]propylamino)tetralin autoradiography were compared both qualitatively and quantitatively. Qualitative evaluation proved that the same brain regions were labeled and that the p-[18F]MPPF labeling is (a) in total agreement with the known distribution of 5-HT1A receptors in rats and (b) characterized by very low nonspecific binding. Quantitative comparison demonstrated that the in vivo labeling pattern obtained with p-[18F]MPPF cannot be explained by differences in regional blood flow, capillary density, or permeability. The 5-HT1A specificity of p-[18F]MPPF and binding reversibility were confirmed in vivo with displacement experiments. Thus, this compound can be used to evaluate parameters characterizing 5-HT1A binding sites in the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2000.0750803.x
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  • 2
    Electronic Resource
    Electronic Resource
    Structure and rheology of aramid solutions: transient rheological and rheooptical measurements (1991)
    s.l. : American Chemical Society
    Macromolecules 24 (1991), S. 1366-1375 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma00006a023
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  • 3
    Electronic Resource
    Electronic Resource
    Small-angle X-ray scattering of aramid fibre (1991)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 24 (1991), S. 709-711 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: Aramid fibres show elongated microvoids parallel to the direction of the fibre axis, resulting in an equatorial streak in the small-angle X-ray scattering (SAXS) pattern. The scattered intensity in the equatorial direction has been measured for three samples of the same fibre: an untreated yarn specimen, yarn in which Ag2S was precipitated and a single filament of the latter. In the case of the untreated yarn, the interpretation of the SAXS pattern is hindered by the presence of residual water in the voids, resulting in a three-phase system. The SAXS pattern of the yarn with precipitated Ag2S follows the theoretical pattern (adapted for the two-dimensional case) for a system with random pores, but the interface between aramid and Ag2S shows fractal properties. The single filament with Ag2S shows a SAXS pattern analogous to that of the fibre with Ag2S, indicating that multiple scattering and interfilament scattering is negligible. It was also found that the Ag2S precipitates in the fibre with preferred orientation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889890012730
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  • 4
    Electronic Resource
    Electronic Resource
    Identification of Gaucher Disease Carriers: Glucocerebrosidase Antigen and DNA Analysis
    Amsterdam : Elsevier
    Biochemical Medicine and Metabolic Biology 50 (1993), S. 190-196 
    Details
    ISSN: 0885-4505
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/bmmb.1993.1061
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  • 5
    Electronic Resource
    Electronic Resource
    Polymer crystal silverware: a fast method for the prediction of polymer crystal structures (1996)
    Springer
    Polymer bulletin 36 (1996), S. 645-652 
    Details
    ISSN: 1436-2449
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Summary A method is presented for the fast prediction of polymer crystal structures. From a stable helical conformation of the polymer chain well packed three dimensional periodic starting structures are generated using an adapted version of M. Blanco's Molecular Silverware algorithm. These structures are then energy-minimised using classical molecular mechanics methods. The method only requires a rough estimate of the crystalline density. No information about crystal class, space group or cell parameters is necessary. Using this method, possible crystal structures of poly(ethylene ketone), Nylon-6,6 and poly(ethylene terephthalate) are calculated. Both the α- and β-structures of poly(ethylene ketone) are correctly predicted. For Nylon-6,6 the lowest-energy structure obtained corresponds to the experimental α-structure. For poly(ethylene terephthalate) a large number of structures are generated using the algorithm. Besides the experimental structure four structures are found with a lower energy than the experimental structure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00342458
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  • 6
    Electronic Resource
    Electronic Resource
    The influence of deposition rate on the electrical properties of thin tellurium films
    Amsterdam : Elsevier
    Thin Solid Films 46 (1977), S. 223-228 
    Details
    ISSN: 0040-6090
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0040-6090(77)90066-9
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  • 7
    Electronic Resource
    Electronic Resource
    A case of type I Gaucher disease with cardiopulmonary amyloidosis and chitotriosidase deficiency (1996)
    Springer
    Virchows Archiv 429 (1996), S. 305-309 
    Details
    ISSN: 1432-2307
    Keywords: Gaucher disease ; Amyloidosis ; Chitotriosidase deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Severe cardiopulmonary amyloidosis developed several months after a total splenectomy in a patient with type 1 Gaucher disease and led within a year to his death at 48 years of age. The autopsy findings were dominated by extensive pulmonary and cardiac amyloid infiltration. No Gaucher cells were found in the lungs. Aside from a glucocerebrosidase deficiency the patient was also deficient in chitotriosidase, an enzyme whose activity is usually greatly increased in the serum of Gaucher patients. Analysis of mutations in the glucocerebrosidase gene revealed heterozygosity for N370S and D409H mutations. The normal amount of glucocerebrosidase was found in the spleen by Western blotting. We suggest that amyloidosis should be considered in the differential diagnosis of severe cardiopulmonary disease in Gaucher patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198347
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  • 8
    Electronic Resource
    Electronic Resource
    Temperature-dependent lipid content and fatty acid composition of three thermophilic bacteria (1985)
    Springer
    Antonie van Leeuwenhoek 51 (1985), S. 155-165 
    Details
    ISSN: 1572-9699
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The lipid content and fatty acid composition of a strain ofBacillus caldolyticus and of two facultative thermophiles (B. flavothermus and strain NZ-2) were analysed after growth at different temperatures. In all three strains the amount of membrane, as a fraction of total cellular dry mass, was found to increase with temperature, however, in varying degrees. Changes of lipid content and protein/lipid ratio inB. caldolyticus between 60°C and 100°C and in strain NZ-2 between 45°C and 70°C were minor; inB. f avothermus the alterations in the 50°C–70°C range were more pronounced. The same was found for changes observed in the phospholipid/total lipid and phospholipid/membrane ratios, and also in the amounts of individual phospholipids. The alterations of the fatty acid composition were most significant inB. caldolyticus, especially between 80°C and 95°C. In contrast, the main changes inB. flavothermus and NZ-2 were found to occur between 30°C and 50°C, and between 45°C and 60°C, respectively. Based on these data, strain NZ-2 could be characterized as the least andB. flavothermus as the most versatile of the three organisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02310009
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  • 9
    Electronic Resource
    Electronic Resource
    Expiratory time constants in mechanically ventilated patients with and without COPD (2000)
    Springer
    Intensive care medicine 26 (2000), S. 1612-1618 
    Details
    ISSN: 1432-1238
    Keywords: Mechanical ventilation Chronic obstructive pulmonary disease Respiratory mechanics Flow-volume curve Time constant Airflow obstruction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective: In mechanically ventilated patients, the expiratory time constant provides information about the respiratory mechanics and the actual time needed for complete expiration. As an easy method to determine the time constant, the ratio of exhaled tidal volume to peak expiratory flow has been proposed. This assumes a single compartment model for the whole expiration. Since the latter has to be questioned in patients with chronic obstructive pulmonary disease (COPD), we compared time constants calculated from various parts of expiration and related these to time constants assessed with the interrupter method. Design: Prospective study. Setting: A medical intensive care unit in a university hospital. Patients: Thirty-eight patients (18 severe COPD, eight mild COPD, 12 other pathologies) were studied during mechanical ventilation under sedation and paralysis. Measurements and results: Time constants determined from flow-volume curves at 100%, the last 75, 50, and 25% of expired tidal volume, were compared to time constants obtained from interrupter measurements. Furthermore, the time constants were related to the actual time needed for complete expiration and to the patient's pulmonary condition. The time constant determined from the last 75% of the expiratory flow-volume curve (RCfv75) was in closest agreement with the time constant obtained from the interrupter measurement, gave an accurate estimation of the actual time needed for complete expiration, and was discriminative for the severity of COPD. Conclusions: In mechanically ventilated patients with and without COPD, a time constant can well be calculated from the expiratory flow-volume curve for the last 75% of tidal volume, gives a good estimation of respiratory mechanics, and is easy to obtain at the bedside.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340000632
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  • 10
    Electronic Resource
    Electronic Resource
    The N370S mutation in the glucocerebrosidase gene of Portuguese type 1 Gaucher patients: Linkage to the PvuII polymorphism (1994)
    Springer
    Journal of inherited metabolic disease 17 (1994), S. 85-88 
    Details
    ISSN: 1573-2665
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mutation N370S accounts for 63% of the mutated glucocerebrosidase alleles of Portuguese type 1 Gaucher patients. It has been shown previously that this mutation is linked to the Pv1.1− form of the PvuII polymorphism and suggested that the N370S mutation in glucocerebrosidase alleles has an Ashkenazi Jewish origin. We have found that in Portuguese type 1 Gaucher patients this mutation is also invariably associated with the Pv1.1− haplotype, despite the fact that there is no evidence of Ashkenazi Jewish background in this population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735401
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