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  • Electronic Resource  (13)
  • 1
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Based on the observation of large conductance states formed by Bacillus thuringiensis Cry toxins in synthetic planar lipid bilayers and the estimation of a pore size of 10–20 Å, it has been proposed that the pore could be formed by an oligomer containing four to six Cry toxin monomers. However, there is a lack of information regarding the insertion of Cry toxins into the membrane and oligomer formation. Here we provide direct evidence showing that the intermolecular interaction between Cry1Ab toxin monomers is a necessary step for pore formation and toxicity. Two Cry1Ab mutant proteins affected in different steps of their mode of action (F371A in receptor binding and H168F in pore formation) were affected in toxicity against Manduca sexta larvae. Binding analysis showed that F371A protein bound more efficiently to M. sexta brush border membrane vesicles when mixed with H168F in a one to one ratio. These mutant proteins also recovered pore-formation activity, measured with a fluorescent dye with isolated brush border membrane vesicles, and toxicity against M. sexta larvae when mixed, showing that monomers affected in different steps of their mode of action can form functional hetero-oligomers.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 51 (1996), S. 0 
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Scientometrics 26 (1993), S. 157-167 
    ISSN: 1588-2861
    Source: Springer Online Journal Archives 1860-2000
    Topics: Information Science and Librarianship , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract The study aims at designing a set of indicators which, integrated altogether, should be albe to inform on the kind of research published in journal articles and its proximity to their specific forefornts. The set of indicators is composed of two subsets, one including information of the authors, “research performers indicators”, and other embodying information of the references used, “source indicators”. The source indicators are compared with the references pattern of specific paradigmatic journals used as standard framework of the research field. Three case studies dealing with the Spanish research on Immunology, Neurosciences and Pharmacognosy will be presented. The application of the indicators gave the following results: Spanish Immunology published in foreign journals was basic in its scope while the one published in domestric journals dealt with applied and clinical Medicine. Neuroscience publsiedh in foreign journals by financed Hospitals appertained to the forefront and presented a broad scope, Neuroscience Published in foreign journals by non-financed Hospitals was applied research and Neuroscience published by Universities, also in foreign journals, represented basic research done in a closed system. The case of Spanish Pharmacognosy is more difficult to interpret as three subject fields are involved (Pharmacology, Chemistry and Botany). The indicators did not clearly differentiate between the research published in domestic and foreign journals, although it seems that Spanish scientists are more interested in the pharmacological and botanical aspect of the natural products than in their chemical structure.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1588-2861
    Source: Springer Online Journal Archives 1860-2000
    Topics: Information Science and Librarianship , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract The coverage of Latin American journals by international databases influences the visibility of these countries' scientific output, and has a direct effect in their activity index per scientific discipline. Local, regional and international character of the most visible Latin American journals in SCI expanded and restricted databases is analysed, as well as its influence in the percentage share of each country in certain disciplines. Suggestions to enhance visibility of local journals are presented.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1588-2861
    Source: Springer Online Journal Archives 1860-2000
    Topics: Information Science and Librarianship , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract International scientific cooperation of Latin American countries amongst themselves, with the USA and with the European Union in the period 1991–1995 was studied. The analysis deepens in the differences per subject area and the influence of the regional axis involved. Collaboration patterns differ according to the scientific size of the latin American countries, the thematic areas and whether a bilateral collaboration or a participation in a multilateral network takes place. Some special characteristics of multi-regional cooperation networks are presented.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Scientometrics 35 (1996), S. 223-235 
    ISSN: 1588-2861
    Source: Springer Online Journal Archives 1860-2000
    Topics: Information Science and Librarianship , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract The delimitation of a research field in bibliometric studies presents the problem of the diversity of subject classifications used in the sources of input and output data. Classification of documents according to thematic codes or keywords is the most accurate method, mainly used in specialised bibliographic or patent databases. Classification of journals in disciplines presents lower specificity, and some shortcomings as the change over time of both journals and disciplines and the increasing interdisciplinarity of research. Differences in the criteria in which input and output data classifications are based obliges to aggregate data in order to match them. Standardization of subject classifications emerges as an important point in bibliometric studies in order to allow international comparisons, although flexibility is needed to meet the needs of local studies.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Scientometrics 15 (1989), S. 621-631 
    ISSN: 1588-2861
    Source: Springer Online Journal Archives 1860-2000
    Topics: Information Science and Librarianship , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract A sample of “Citation Classics” in three scientific fields was studied to uncover citing motivations. The classics were classified into basic research, methods and reviews. Number of citations received per classic, number of authors, and age of classic per category and scientific field were the parameters studied. Journals and countries accounting for the highest incidence of classics were examined. A striking parallelism was found in the parameters applied to the categories in the scientific fields studied. This parallelism suggests similar citing habits of scientists in the fields studied which should be reflected in the structures of science obtained through citation grounded bibliometric models.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Scientometrics 24 (1992), S. 137-147 
    ISSN: 1588-2861
    Source: Springer Online Journal Archives 1860-2000
    Topics: Information Science and Librarianship , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract Collaborative research in Spain in the field of pharmacology is studied. Co-authored papers in periodicals were one of the indicators used to quantify collaborative research results. Through Spanish publications of pharmacologists, collaborations between different institutions in the same city are mostly detected. Through foreign papers quite different networks were found, both amongst Spanish cities and with institutions in other countries. In case of Spanish pharmaceutical industry questionnaires were used to determine their links with other institutions, mostly through research projects.
    Type of Medium: Electronic Resource
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