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  • 1
    Electronic Resource
    Electronic Resource
    Changes in the cytoskeletal proteins, sarcoplasmic reticulum, and capillaries in acute relaxant-steroid myopathy (ARSM) in contrast to the corticosteroid myopathy (1999)
    Springer
    Acta neuropathologica 97 (1999), S. 515-519 
    Details
    ISSN: 1432-0533
    Keywords: Key words Muscle relaxant ; Pancuronium ; Corticosteroids ; Dystrophin ; Myopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Since we reported a case of acute relaxant-steroid myopathy (ARSM) in 1994, we continued histological studies and compared the findings with those in a case of corticosteroid myopathy (CM). It was revealed that (1) dystrophin, spectrin, beta dystroglycan, and sarcoglycans on the cell surface were decreased, (2) regular arrangement of the sarcoplasmic reticulum was lost, and (3) some capillaries were degenerated. Since none of these changes were seen in CM, it became clear that ARSM is different from CM. It was estimated that continuous administration of non-depolarizing muscle relaxant produces a state akin to denervation. Combination of denervation, immobilization and circulatory disturbance in ARSM not only augments the effects of corticosteroids, but they produce changes different from CM, namely impairment of the cell membrane system (both internal and external) and capillary degeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010051022
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Laryngeal electromyography with separated surface electrodes in patients with multiple system atrophy presenting with vocal cord paralysis (1994)
    Springer
    Journal of neurology 241 (1994), S. 551-556 
    Details
    ISSN: 1432-1459
    Keywords: Multiple system atrophy ; Vocal cord paralysis ; Posterior cricoarytenoid muscle ; Laryngeal electromyography ; Surface electrode
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract When recording the activity of the posterior cricoarytenoid muscle (PCA) with surface electrodes, there is contamination from the surrounding muscles such as the cricopharyngeal muscle. We therefore devised a new oesophageal catheter electrode of the separate type, having three individual surface electrodes for the PCA, cricopharyngeal muscle and diaphragm. The records obtained with this catheter demonstrated satisfactory separation between PCA and cricopharyngeal muscle activities. We used this catheter in patients with multiple system atrophy presenting with vocal cord paralysis, who were awake or asleep. There were two interesting electromyographical findings, which were inspiratory activity of the adductor muscle (the thyroarytenoid muscle) and fade-out of the abductor muscle, that is, PCA activity during sleep. Although vocal cord paralysis is one of the most serious life-threatening complications, the precise mechanism has not been clarified. We believe that our catheter may be useful in investigating the mechanism of vocal cord paralysis which could cause sudden death in neurodegenerative disorders, including multiple system atrophy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00873518
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    Paper (German National Licenses)
    Fulltext
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