ISSN:
1438-2199
Keywords:
Keywords: Amino acids
;
Glutamate
;
Neuroprotection
;
NMDA receptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary. NPS Pharmaceuticals, Inc. (NPS) has synthesized a series of open-channel blockers with varying potencies at the NMDA receptor. NPS 1506 (Fig. 1) is a moderate affinity antagonist that inhibits NMDA/glycine-induced increases in cytosolic calcium in cultured rat cerebellar granule cells (IC50 = 476 nM) and displaces the binding of [3H]MK-801 to rat cortical membranes (IC50 = 664 nM).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s007260070047
Permalink