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  • 1
    Electronic Resource
    Electronic Resource
    Lichen planus: study with anti-human T lymphocyte antigen (anti-HTLA) serum on frozen tissue sections (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 98 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The lymphocytic infiltrate of lichen planus was studied by the identification of the human T lymphocyte antigen in frozen tissue sections using specific anti-human T lymphocytes antigen antiserum. The infiltrate was shown to be composed principally of T lymphocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb03576.x
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  • 2
    Electronic Resource
    Electronic Resource
    IMMUNOINTERVENTION IN PSORIASIS WITH ANTI–CD4 ANTIBODIES (1994)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 33 (1994), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1994.tb01062.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cutaneous and Mucosal Warts (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 21 (1982), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : The clinical and histopathological study of cutaneous and mucosal warts demonstrates divergences between clinical and histopathological diagnoses among the group of myrmecias, mosaics, acrodigitate, and common warts. There is correlations criteria (when considered separately), such as hyperkeratosis and absence at keratohyaline granules in flat warts, and in ano-genital vegetations. The existence of clinical and histological overlaps emphasizes that it is not clear whether these cases are rare clinical varieties caused by as yet unknown types of human papillomaviruses, or rather by differences in the degree of keratinization at different sites in the body.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1982.tb00508.x
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  • 4
    Electronic Resource
    Electronic Resource
    Cell-mediated Immunity in Wart Infection (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 21 (1982), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: : The role of cell-mediated immunity (CMI) in wart infection was demonstrated. The correlation with humoral immunity was also suggested. Patients with cell-mediated immune deficiency were found to be more susceptible to wart infection than those with humoral immune deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1982.tb00510.x
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  • 5
    Electronic Resource
    Electronic Resource
    Sequential enumeration of peripheral blood T cell subsets in lichen planus (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 9 (1984), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Peripheral blood T lymphocytes and T cell subsets were examined in fifteen patients with lichen planus prior to and for 4 months during treatment.The percentages of different T cell sub-populations were defined by indirect immunofluorescence using monoclonal antibodies OKT3, OKT4 and OKT8. These are specific markers of total T cells, helper-inducer T cells and suppressor-cytotoxic T cells respectively.Decreased percentages of suppressor T cells and elevated helper suppressor ratios were observed before treatment and after 1 month of therapy. These changes had disappeared by the second month of treatment, by which time all the lesions had healed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1984.tb00792.x
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  • 6
    Electronic Resource
    Electronic Resource
    Decreased levels of T-cells and cells with suppressor T-cell phenotype as defined by specific monoclonal antibodies in patients with atopic dermatitis (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 7 (1982), S. 0 
    Details
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: peripheral blood cells from forty patients with atopic dermatitis and elevated serum IgE levels were studied by indirect immunofluorescence using monoclonal antibodies OKT3, OKT4, OKT8 to, respectively, human T cells, helper-inducer and suppressor-cytotoxic T cell subsets.Decreased T cells with the suppressor-cytotoxic phenotype, with an abnormal balance between helper and suppressor cell subsets, and decreased peripheral blood T cells counts were found as compared to controls. Results were similar in the three age-matches group (4 months–2 years, 2–15 years, 15–50 years) studied.No correlation could be established between serum IgE levels and the elevated helper/suppressor cell ratios.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2230.1982.tb02468.x
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  • 7
    Electronic Resource
    Electronic Resource
    Keratin polypeptides distribution in normal and diseased human epidermis and oral mucosa (1980)
    Springer
    Virchows Archiv 388 (1980), S. 273-288 
    Details
    ISSN: 1432-2307
    Keywords: Keratin polypeptides ; Epidermis ; Oral mucosa ; Epithelial differentiation ; Malignant transformation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immune sera against total keratin and keratin polypeptide subunits were induced in guinea pigs, using the different bands of SDS polyacrylamide gel electrophoresis of fibrous proteins of stratum corneum, derived from normal human epidermis. The distribution of the different polypeptides was studied in numerous human biopsies of normal epidermis, normal oral mucosa and epidermal and mucosal inflammatory, premalignant and malignant lesions using the indirect immunoperoxidase method. Antisera against total keratin (TK) and against the keratin polypeptide of M.W. 55,000 dalton (55K) labelled all keratinocytes in normal and pathological conditions. These antisera may be useful for the histodifferentiation in diagnostic pathology. Atisera against the keratin polypeptides of M.W. 67,000 (67K) and 62,000 dalton (62K) identified only keratin antigens in the spinous, granular and keratinized layer of normal epidermis and oral mucosa. No labelling of the basal layer was achieved with these immune sera. However, there were important differences in the distribution of these keratin antigens in altered epithelia which may be of value in the differential diagnosis of inflammatory, premalignant and malignant lesions of the skin and oral mucosa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430859
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  • 8
    Electronic Resource
    Electronic Resource
    Intracellular keratins in normal and pathological bronchial mucosa (1982)
    Springer
    Virchows Archiv 395 (1982), S. 87-98 
    Details
    ISSN: 1432-2307
    Keywords: Bronchial mucosa ; Cell suspension ; Lung carcinomas ; Keratin polypeptides ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of intracellular keratins was investigated in normal bronchial epithelium and in several morphologically distinct forms of respiratory tract carcinomas. This study was performed with two different experimentally produced antisera against normal human stratum corneum keratin and against keratin protein of MW 67000 dalton, using indirect immunofluorescence and immunoperoxidase methods on tissue sections and cell suspensions. In normal bronchial epithelium, the basal cells were strongly labelled by both antisera. The ciliated columnar cells appeared devoid of cytokeratins in tissue sections but were strongly labelled with both antisera in cell suspensions. The goblet cells remained negative in every case. In squamous metaplasia of the bronchus, all epithelial cells were unevenly stained with both antisera. Among tumours, only the squamous cell carcinomas were strongly labelled by both antisera. Primary lung adenocarcinoma appeared weakly positive, whereas metastatic lung carcinomas, undifferentiated lung carcinomas, oat cell tumours, carcinoid tumours were negative. The immunocytochemical determination of keratins appears to be of value in the study of normal and abnormal epithelial differentiation, in the diagnosis of poorly differentiated carcinomas and in their distinction from metastatic tumours of the lung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443487
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  • 9
    Electronic Resource
    Electronic Resource
    Histological and ultrastructural effects of cyclosporin A on normal human skin xenografted on to nude mice (1990)
    Springer
    Virchows Archiv 416 (1990), S. 505-511 
    Details
    ISSN: 1432-2307
    Keywords: Cyclosporin A ; Human skin xenografts ; Histology ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cyclosporin A (CsA) is a potent immunosuppressant with a selective activity on T-helper lymphocytes. However, CsA also exerts biological effects on non-lymphoid cells (fibroblasts, endothelial and epithelial cells). CsA can inhibit in vivo and in vitro DNA synthesis of epidermal keratinocytes (EK) and induces in vivo morphological alterations of kidney epithelial cells. In the present study we investigated the in vivo effects of a short-term CsA treatment (50 mg/kg per day) on DNA synthesis (evaluated through 5-bromo-2′-deoxyuridine incorporation) and on the histological features of normal human skin xenografted (NHSX) on to congenitally athymic nude mice. When compared with control NHSX, CsA induced a statistically significant inhibition of DNA synthesis of NHSX EK. At the light- and electron-microscopic level, apart from a decrease in the thickness of the viable epidermis of NHSX (statistically non-significant), no noticeable differences between treated and control NHSX could be detected. EK, Langerhans cells and melanocytes appeared morphologically unaffected by CsA and no signs of acute toxicity (giant mitochondria, vacuolization, microcalcifications) were seen. These results suggest that CsA exerts a subtle effect on human EK; indeed, despite an unequivocal antiproliferative activity, no significant histological changes related to the acute CsA toxicity seem to be induced on the various epidermal cell types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01600301
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  • 10
    Electronic Resource
    Electronic Resource
    Immunomorphological and ultrastructural aspects of keratinocyte migration in epidermal wound healing (1981)
    Springer
    Virchows Archiv 392 (1981), S. 217-230 
    Details
    ISSN: 1432-2307
    Keywords: Epidermal repair ; Migration ; Fine and intermediate filaments ; Keratinocyte differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Epidermal repair was studied after the induction of a suction blister on human abdominal skin. The investigation was concerned with keratinocyte migration from the epidermal wound margins and changes at the dermo-epidermal junction. Specific antisera against actin and keratin proteins showed the distribution of fine and intermediate filaments within marginal epithelial cells. Pemphigus- and pemphigoid-autoantibodies allowed the evaluation of the decomposition of extracellular substances. Transmission and scanning electron microscopy were used to analyze the submicroscopical changes in intra- and extraepithelial structures. It was found that suprabasal cells, defined by the presence of keratin polypeptides of 67000 daltons, moved out of the epidermis, thus covering the wound. These cells were strongly labelled by actin-antibodies at the wound margins. The expression of pemphigus antigen was not changed at the wound margins. Components of the basal membrane zone (bullous pemphigoid antigen) were not detected immunohistologically before keratinocytes were present at the surface of the wound. This finding supports the hypothesis that the substances at the junctional zone are partly of epithelial origin. Transmission electron microscopy showed that the lamina densa was present across the wound hiatus. In addition, the development of desmosomes and hemidesmosomes during wound healing was demonstrated. Scanning electron microscopy did not support the concept of cell movement as a coherent sheet, but rather that of an “ameboid” type of cell movement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430822
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