ISSN:
1573-935X
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The temperature dependences of the chemical shifts of the proflavin protons in a mixture with the deoxytetraribonucleoside diphosphate 5′-d(GpCpGpC) in aqueous solution were investigated on a pulse NMR spectrometer (500 MHz). A procedure is proposed for calculating the mole fractions of various associates in solution as a function of the temperature. The Gibbs free energies, enthalpies, and entropies of the reactions forming the 1∶1, 1∶2, 2∶1, and 2∶2 complexes of proflavin with the tetranucleotide were determined. The results are evidence of a vital role of hydrophobic interactions in the formation of complexes of the dye with the duplex of the tetramer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00532105
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